A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing

Vartul Sangal, Andreas Burkovski, Alison C. Hunt, Becky Edwards, Jochen Blom, Paul A. Hoskisson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.

LanguageEnglish
Pages54-57
Number of pages4
JournalInfection, Genetics and Evolution
Volume21
Early online date5 Nov 2013
DOIs
Publication statusPublished - Jan 2014

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Corynebacterium diphtheriae
genomics
genome
Genome
phylogenetics
gene
Molecular Typing
phylogeny
Genes
method
genes
methodology

Keywords

  • biovar differentiation
  • corynebacterium diphtheriae
  • genomic analyses
  • genetic basis
  • genome sequencing

Cite this

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abstract = "The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.",
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A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing. / Sangal, Vartul; Burkovski, Andreas; Hunt, Alison C.; Edwards, Becky; Blom, Jochen; Hoskisson, Paul A.

In: Infection, Genetics and Evolution, Vol. 21, 01.2014, p. 54-57.

Research output: Contribution to journalArticle

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AU - Blom, Jochen

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