A hybrid three-dimensional nanofabrication method for producing vascular tissue engineering scaffold

N. Gadegaard, K. Seunarine, David J.A. Smith, D.O. Meredith, C.D.W. Wilkinson, M.O. Riehle

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    There is a trend towards the production of lithographically defined materials for biological applications. The field of nanobio technology is rapidly growing and so is demand for materials nanostructured in three dimensions. Here we present a hybrid approach where where we use electron beam lithography, photolithography and hot embossing to produce membranes patterned on both sides. The double sided patterned membranes were subsequently rolled to create the three dimensional tissue construct aimed at vascular repair. The mechanical properties such as bending and bursting pressure were also investigated.
    Original languageEnglish
    Pages (from-to)7415-7419
    Number of pages4
    JournalJournal of Applied Physics
    Issue number9
    Publication statusPublished - Sep 2008


    • embossing
    • imprint lithography
    • 3D
    • electron beam lithography
    • polymer phase separation

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