A high-throughput microfluidic system for the simultaneous formation of droplet-interface bilayer arrays

Barbara Schlicht, Michele Zagnoni

Research output: Contribution to conference › Proceeding › peer-review

Abstract

The ability to form artificial lipid membranes in a reliable, high-throughput lab-on-a-chip format has the potential to advance membrane protein studies and the development of sensitive molecular biosensors, ultimately impacting on the development of novel and low-cost synthetic approaches to drug screening. Existing methods are limited in terms of their automation, throughput and ease of use. We have developed a microfluidic system that allows the formation, alternation, desired positioning and long-term storage of arrays of droplet-interface-bilayers (DIBs). By encapsulating the desired cocktail of liposomes and metabolites into phospholipid-stabilized water-in-oil (W/O) droplets, hundreds of DIBs were characterized using fluorescence-based assays.
Original languageEnglish
Number of pages3
Publication statusPublished - 31 Oct 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - MicroTAS 2013 - Freiburg, Germany
Duration: 27 Oct 2013 → 31 Oct 2013
http://microtasconferences.org/microtas2013/

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - MicroTAS 2013
Abbreviated titleMicroTAS 2013
CountryGermany
CityFreiburg
Period27/10/13 → 31/10/13
Internet address

Keywords

  • microfluidics
  • lab - on - a - chip
  • passive channel networks
  • droplet - interface - bilayers

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