Projects per year
The ability to form artificial lipid membranes in a reliable, high-throughput lab-on-a-chip format has the potential to advance membrane protein studies and the development of sensitive molecular biosensors, ultimately impacting on the development of novel and low-cost synthetic approaches to drug screening. Existing methods are limited in terms of their automation, throughput and ease of use. We have developed a microfluidic system that allows the formation, alternation, desired positioning and long-term storage of arrays of droplet-interface-bilayers (DIBs). By encapsulating the desired cocktail of liposomes and metabolites into phospholipid-stabilized water-in-oil (W/O) droplets, hundreds of DIBs were characterized using fluorescence-based assays.
|Number of pages||3|
|Publication status||Published - 31 Oct 2013|
|Event||17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - MicroTAS 2013 - Freiburg, Germany|
Duration: 27 Oct 2013 → 31 Oct 2013
|Conference||17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - MicroTAS 2013|
|Abbreviated title||MicroTAS 2013|
|Period||27/10/13 → 31/10/13|
- lab - on - a - chip
- passive channel networks
- droplet - interface - bilayers
1/10/11 → 25/09/19
Project: Research Studentship - Internally Allocated
Schlicht, B., & Zagnoni, M. (2013). A high-throughput microfluidic system for the simultaneous formation of droplet-interface bilayer arrays. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - MicroTAS 2013, Freiburg, Germany.