A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function

H C Whalley; B S Pickard; A M McIntosh; R Zuliani; E C Johnstone; D H R Blackwood; S M Lawrie; W J Muir; J Hall

doi:10.1038/mp.2009.7

A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function

H C Whalley, B S Pickard, A M McIntosh, R Zuliani, E C Johnstone, D H R Blackwood, S M Lawrie, W J Muir, J Hall

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.

Original language	English
Pages (from-to)	467-468
Number of pages	2
Journal	Molecular Psychiatry
Volume	14
Issue number	5
DOIs	https://doi.org/10.1038/mp.2009.7
Publication status	Published - May 2009

Keywords

bipolar disorder
hippocampal function
biomedical sciences
receptors
kanic acid

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10.1038/mp.2009.7

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abstract = "The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.",

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AU - Whalley, H C

AU - Pickard, B S

AU - McIntosh, A M

AU - Zuliani, R

AU - Johnstone, E C

AU - Blackwood, D H R

AU - Lawrie, S M

AU - Muir, W J

AU - Hall, J

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AB - The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.

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KW - hippocampal function

KW - biomedical sciences

KW - receptors

KW - kanic acid

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ER -

A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function

Abstract

Keywords

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