Abstract
The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.
Original language | English |
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Pages (from-to) | 467-468 |
Number of pages | 2 |
Journal | Molecular Psychiatry |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2009 |
Keywords
- bipolar disorder
- hippocampal function
- biomedical sciences
- receptors
- kanic acid