A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function

H C Whalley, B S Pickard, A M McIntosh, R Zuliani, E C Johnstone, D H R Blackwood, S M Lawrie, W J Muir, J Hall

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.
Original languageEnglish
Pages (from-to)467-468
Number of pages2
JournalMolecular Psychiatry
Volume14
Issue number5
DOIs
Publication statusPublished - May 2009

Keywords

  • bipolar disorder
  • hippocampal function
  • biomedical sciences
  • receptors
  • kanic acid

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