A general model of coupled drug release and tissue absorption for drug delivery devices

Sean McGinty, Giuseppe Pontrelli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In this paper we present a general model of drug release from a drug delivery device and the subsequent transport in biological tissue. The model incorporates drug diffusion, dissolution and solubility in the polymer coating, coupled with diffusion, convection and reaction in the biological tissue. Each layer contains bound and free drug phases so that the resulting model is a coupled two-phase two-layer system of partial differential equations. One of the novelties is the generality of the model in each layer. Within the drug coating, our model includes diffusion as well as three different models of dissolution. We show that the model may also be used in cases where dissolution is rapid or not relevant, and additionally when drug release is not limited by its solubility. Within the biological tissue, the model can account for non-linear saturable reversible binding, with linear reversible binding and linear irreversible binding being recovered as special cases. The generality of our model will allow the simulation of the release from a wide range of drug delivery devices encompassing many different applications. To demonstrate the efficacy of our model we simulate results for the particular application of drug release from arterial stents.
LanguageEnglish
Pages327-336
Number of pages10
JournalJournal of Controlled Release
Volume217
Early online date21 Sep 2015
DOIs
Publication statusPublished - 10 Nov 2015

Fingerprint

Drug Delivery
Drugs
Absorption
Equipment and Supplies
Pharmaceutical Preparations
Solubility
Biological Tissue
Biological Transport
Dissolution
Convection
Model
Stents
Polymers
Coating
Stent
Drug Liberation
Convection-diffusion
Reaction-diffusion
Systems of Partial Differential Equations
Diffusion Model

Keywords

  • drug delivery
  • dissolution
  • diffusion, binding, two-phase equations, coupled partial
  • binding
  • two-phase equations
  • coupled partial differential equations

Cite this

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A general model of coupled drug release and tissue absorption for drug delivery devices. / McGinty, Sean; Pontrelli, Giuseppe.

In: Journal of Controlled Release, Vol. 217, 10.11.2015, p. 327-336.

Research output: Contribution to journalArticle

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AU - Pontrelli, Giuseppe

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AB - In this paper we present a general model of drug release from a drug delivery device and the subsequent transport in biological tissue. The model incorporates drug diffusion, dissolution and solubility in the polymer coating, coupled with diffusion, convection and reaction in the biological tissue. Each layer contains bound and free drug phases so that the resulting model is a coupled two-phase two-layer system of partial differential equations. One of the novelties is the generality of the model in each layer. Within the drug coating, our model includes diffusion as well as three different models of dissolution. We show that the model may also be used in cases where dissolution is rapid or not relevant, and additionally when drug release is not limited by its solubility. Within the biological tissue, the model can account for non-linear saturable reversible binding, with linear reversible binding and linear irreversible binding being recovered as special cases. The generality of our model will allow the simulation of the release from a wide range of drug delivery devices encompassing many different applications. To demonstrate the efficacy of our model we simulate results for the particular application of drug release from arterial stents.

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