A double-blind, clinical evaluation of facial augmentation treatments: a comparison of PRI 1, PRI 2, Zyplast® and Perlane®

Jeff Downie, Zhili Mao, Tsz-Wai Rachel Lo, Sarah Barry, Mitchum Bock, J. Paul Siebert, Adrian Bowman, Ashraf Ayoub

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast? (purified bovine collagen) and Perlane? (cross-linked hyaluronic acid gel). Methods: 79 females (aged 25?55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane? (23 patients), Zyplast? (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry. Results: All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast? showed similar lip volume gains, with Perlane? showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment, however, Perlane? maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast?. Patient satisfaction scores were similar, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p = 0.052). Treatment was well-tolerated, with ?cold sore? being the most common adverse event. Conclusions: Results showed that PRI 1 and PRI 2 were comparable to Perlane? and Zyplast? as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.
LanguageEnglish
Pages1636-1643
Number of pages8
JournalJournal of Plastic, Reconstructive & Aesthetic Surgery
Volume62
Issue number12
Early online date4 Nov 2008
DOIs
Publication statusPublished - 31 Dec 2009

Fingerprint

Lip
Photogrammetry
Collagen
Therapeutics
Herpes Labialis
Hyaluronic Acid
Patient Satisfaction
Perlane
glutaraldehyde-cross-linked collagen
Swine
Gels
Research Personnel
Skin
Dermal Fillers

Keywords

  • dermal fillers
  • collagen
  • lip
  • ageing
  • stereophotogrammetry
  • 3D soft tissue analysis

Cite this

Downie, Jeff ; Mao, Zhili ; Lo, Tsz-Wai Rachel ; Barry, Sarah ; Bock, Mitchum ; Siebert, J. Paul ; Bowman, Adrian ; Ayoub, Ashraf. / A double-blind, clinical evaluation of facial augmentation treatments : a comparison of PRI 1, PRI 2, Zyplast® and Perlane®. In: Journal of Plastic, Reconstructive & Aesthetic Surgery. 2009 ; Vol. 62, No. 12. pp. 1636-1643.
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abstract = "Background: Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast? (purified bovine collagen) and Perlane? (cross-linked hyaluronic acid gel). Methods: 79 females (aged 25?55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane? (23 patients), Zyplast? (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry. Results: All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast? showed similar lip volume gains, with Perlane? showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment, however, Perlane? maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast?. Patient satisfaction scores were similar, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p = 0.052). Treatment was well-tolerated, with ?cold sore? being the most common adverse event. Conclusions: Results showed that PRI 1 and PRI 2 were comparable to Perlane? and Zyplast? as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.",
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A double-blind, clinical evaluation of facial augmentation treatments : a comparison of PRI 1, PRI 2, Zyplast® and Perlane®. / Downie, Jeff; Mao, Zhili; Lo, Tsz-Wai Rachel; Barry, Sarah; Bock, Mitchum; Siebert, J. Paul; Bowman, Adrian; Ayoub, Ashraf.

In: Journal of Plastic, Reconstructive & Aesthetic Surgery, Vol. 62, No. 12, 31.12.2009, p. 1636-1643.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A double-blind, clinical evaluation of facial augmentation treatments

T2 - Journal of Plastic, Reconstructive & Aesthetic Surgery

AU - Downie, Jeff

AU - Mao, Zhili

AU - Lo, Tsz-Wai Rachel

AU - Barry, Sarah

AU - Bock, Mitchum

AU - Siebert, J. Paul

AU - Bowman, Adrian

AU - Ayoub, Ashraf

PY - 2009/12/31

Y1 - 2009/12/31

N2 - Background: Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast? (purified bovine collagen) and Perlane? (cross-linked hyaluronic acid gel). Methods: 79 females (aged 25?55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane? (23 patients), Zyplast? (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry. Results: All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast? showed similar lip volume gains, with Perlane? showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment, however, Perlane? maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast?. Patient satisfaction scores were similar, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p = 0.052). Treatment was well-tolerated, with ?cold sore? being the most common adverse event. Conclusions: Results showed that PRI 1 and PRI 2 were comparable to Perlane? and Zyplast? as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.

AB - Background: Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast? (purified bovine collagen) and Perlane? (cross-linked hyaluronic acid gel). Methods: 79 females (aged 25?55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane? (23 patients), Zyplast? (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry. Results: All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast? showed similar lip volume gains, with Perlane? showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment, however, Perlane? maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast?. Patient satisfaction scores were similar, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p = 0.052). Treatment was well-tolerated, with ?cold sore? being the most common adverse event. Conclusions: Results showed that PRI 1 and PRI 2 were comparable to Perlane? and Zyplast? as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.

KW - dermal fillers

KW - collagen

KW - lip

KW - ageing

KW - stereophotogrammetry

KW - 3D soft tissue analysis

UR - http://eprints.gla.ac.uk/25983/

UR - https://www.sciencedirect.com/journal/journal-of-plastic-reconstructive-and-aesthetic-surgery

U2 - 10.1016/j.bjps.2008.06.056

DO - 10.1016/j.bjps.2008.06.056

M3 - Article

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SP - 1636

EP - 1643

JO - Journal of Plastic, Reconstructive & Aesthetic Surgery

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SN - 1748-6815

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