A continuum model of the within-animal population dynamics of E-coli O157

J.C. Wood, D.C. Speirs, S.W. Naylor, G. Gettinby, I.J. McKendrick

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The high level of human morbidity caused by E. coli O157:H7 necessitates an improved understanding of the infection dynamics of this bacterium within the bovine reservoir. Until recently, a degree of uncertainty surrounded the issue of whether these bacteria colonize the bovine gut and as yet, only incomplete in-vivo datasets are available. Such data typically consist of bacterial counts from fecal samples. The development of a deterministic model, which has been devised to make good use of such data, is presented. A partial differential equation, which includes advection, diffusion and growth terms, is used to model the (unobserved) passage of bacteria through the bovine gut. A set of experimentally-obtained fecal count data is used to parameterize the model. Between-animal variability is found to be greater than between-strain variability, with some results adding further weight to the hypothesis that E. coli O157:H7 can colonize the bovine gastrointestinal tract.
LanguageEnglish
Pages425-443
Number of pages18
JournalJournal of Biological Systems
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Population dynamics
Escherichia coli O157
Population Dynamics
Continuum Model
Bacteria
Escherichia coli
Escherichia Coli
Animals
population dynamics
Animal Models
cattle
bacterium
bacteria
animals
Advection-diffusion
Morbidity
Parameterise
digestive system
Count Data
Advection

Keywords

  • advection-diffusion equation
  • method of lines
  • triangular distribution
  • maximum likelihood
  • E. coli O157

Cite this

Wood, J.C. ; Speirs, D.C. ; Naylor, S.W. ; Gettinby, G. ; McKendrick, I.J. / A continuum model of the within-animal population dynamics of E-coli O157. In: Journal of Biological Systems. 2006 ; Vol. 14, No. 3. pp. 425-443.
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A continuum model of the within-animal population dynamics of E-coli O157. / Wood, J.C.; Speirs, D.C.; Naylor, S.W.; Gettinby, G.; McKendrick, I.J.

In: Journal of Biological Systems, Vol. 14, No. 3, 09.2006, p. 425-443.

Research output: Contribution to journalArticle

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