A computational model of blood flow in normal and diseased arteries

Lauren Johnston, Asimina Kazakidi

Research output: Contribution to conferenceAbstract

Abstract

Obesity in children is quickly becoming one of the major challenges of the 21st century. The health risks such obese children and adolescents suffer from are increased levels of blood cholesterol, early signs of cardiovascular disease (CVD) and other serious health problems. Computational fluid dynamic methods can quantify disturbed blood flow mathematically and thus provide a more powerful approach to haemodynamic investigation.

The aim of this research project was to develop and apply a simplified model of an arterial segments for young normal-weight and obese patients, in order to analyse the effects of blood flow. By developing a mathematical model based on a 3-element Windkessel model, the haemodynamics of the arterial system in terms of resistance and compliance were defined. The model is adaptable for both children and adults and produces plots with output values for parameters such as blood pressure.
Throughout the study, flow-related disease markers - which provide an indication of cardiovascular disease (CVD) in an individual - were identified. The literature review compared obese and normal-weight children in terms of (1) systolic blood pressure, (2) pulse wave velocity, (3) baseline brachial flow-mediated vasodilation, and (4) carotid intima-media thickness and stiffness. All four of these disease markers were found to have greater values in obese children than normal-weight children – indicating presence or onset of CVD.

The research undertaken in this study provides a greater understanding of blood flow in obese and normal-weight children while the mathematical model provides a quantitative representation of blood flow for any individual.

Conference

ConferenceBritish Conference of Undergraduate Research
CountryUnited Kingdom
CitySheffield
Period12/04/1813/04/18
Internet address

Fingerprint

Blood
Arteries
Blood pressure
Hemodynamics
Weights and Measures
Cardiovascular Diseases
Blood Pressure
Mathematical models
Theoretical Models
Health risks
Cholesterol
Medical problems
Carotid Intima-Media Thickness
Pulse Wave Analysis
Pediatric Obesity
Health
Hydrodynamics
Computational fluid dynamics
Research
Vasodilation

Keywords

  • obesity
  • blood flow
  • cardiovascular disease (CVD)
  • children

Cite this

Johnston, L., & Kazakidi, A. (2018). A computational model of blood flow in normal and diseased arteries. Abstract from British Conference of Undergraduate Research, Sheffield, United Kingdom.
Johnston, Lauren ; Kazakidi, Asimina. / A computational model of blood flow in normal and diseased arteries. Abstract from British Conference of Undergraduate Research, Sheffield, United Kingdom.1 p.
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Johnston, L & Kazakidi, A 2018, 'A computational model of blood flow in normal and diseased arteries' British Conference of Undergraduate Research, Sheffield, United Kingdom, 12/04/18 - 13/04/18, .

A computational model of blood flow in normal and diseased arteries. / Johnston, Lauren ; Kazakidi, Asimina.

2018. Abstract from British Conference of Undergraduate Research, Sheffield, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - A computational model of blood flow in normal and diseased arteries

AU - Johnston,Lauren

AU - Kazakidi,Asimina

PY - 2018/4/12

Y1 - 2018/4/12

N2 - Obesity in children is quickly becoming one of the major challenges of the 21st century. The health risks such obese children and adolescents suffer from are increased levels of blood cholesterol, early signs of cardiovascular disease (CVD) and other serious health problems. Computational fluid dynamic methods can quantify disturbed blood flow mathematically and thus provide a more powerful approach to haemodynamic investigation.The aim of this research project was to develop and apply a simplified model of an arterial segments for young normal-weight and obese patients, in order to analyse the effects of blood flow. By developing a mathematical model based on a 3-element Windkessel model, the haemodynamics of the arterial system in terms of resistance and compliance were defined. The model is adaptable for both children and adults and produces plots with output values for parameters such as blood pressure.Throughout the study, flow-related disease markers - which provide an indication of cardiovascular disease (CVD) in an individual - were identified. The literature review compared obese and normal-weight children in terms of (1) systolic blood pressure, (2) pulse wave velocity, (3) baseline brachial flow-mediated vasodilation, and (4) carotid intima-media thickness and stiffness. All four of these disease markers were found to have greater values in obese children than normal-weight children – indicating presence or onset of CVD. The research undertaken in this study provides a greater understanding of blood flow in obese and normal-weight children while the mathematical model provides a quantitative representation of blood flow for any individual.

AB - Obesity in children is quickly becoming one of the major challenges of the 21st century. The health risks such obese children and adolescents suffer from are increased levels of blood cholesterol, early signs of cardiovascular disease (CVD) and other serious health problems. Computational fluid dynamic methods can quantify disturbed blood flow mathematically and thus provide a more powerful approach to haemodynamic investigation.The aim of this research project was to develop and apply a simplified model of an arterial segments for young normal-weight and obese patients, in order to analyse the effects of blood flow. By developing a mathematical model based on a 3-element Windkessel model, the haemodynamics of the arterial system in terms of resistance and compliance were defined. The model is adaptable for both children and adults and produces plots with output values for parameters such as blood pressure.Throughout the study, flow-related disease markers - which provide an indication of cardiovascular disease (CVD) in an individual - were identified. The literature review compared obese and normal-weight children in terms of (1) systolic blood pressure, (2) pulse wave velocity, (3) baseline brachial flow-mediated vasodilation, and (4) carotid intima-media thickness and stiffness. All four of these disease markers were found to have greater values in obese children than normal-weight children – indicating presence or onset of CVD. The research undertaken in this study provides a greater understanding of blood flow in obese and normal-weight children while the mathematical model provides a quantitative representation of blood flow for any individual.

KW - obesity

KW - blood flow

KW - cardiovascular disease (CVD)

KW - children

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M3 - Abstract

ER -

Johnston L, Kazakidi A. A computational model of blood flow in normal and diseased arteries. 2018. Abstract from British Conference of Undergraduate Research, Sheffield, United Kingdom.