A comparison of the effects of aminopyridines on isolated chicken and rat skeletal muscle preparations

A. L. Harvey, I. G. Marshall

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1. 1. In the chick biventer cervicis preparation, 4-aminopyridine and 3,4-diaminopyridine selectively augmented indirectly elicited twitches. 2. 2. In the rat hemidiaphragm preparation, both indirectly and directed elicited twitches were augmented. The augmentation was more rapid for indirectly elicited twitches and the twitches became repetitive. 3. 3. The aminopyridines are concluded to facilitate neuromuscular transmission in both species, but increase contractility only in rat. 4. 4. The aminopyridines are suggested to act mainly by inhibiting membrane potassium conductance. Aminopyridine binding sites on the potassium channels may be different in chick and rat muscle. Alternatively, augmentation of contractility in the rat may involve an additional mechanism.

LanguageEnglish
Pages161-165
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume58
Issue number2
DOIs
Publication statusPublished - 1 Jan 1977

Fingerprint

Aminopyridines
Chickens
Skeletal Muscle
4-Aminopyridine
Potassium Channels
Potassium
Binding Sites
Muscles
Membranes

Keywords

  • 3,4 diaminopyridine
  • 4 aminopyridine
  • erabutoxin
  • tubocurarine chloride
  • animal experiment
  • muscle contractility
  • muscle contraction
  • neuromuscular transmission
  • comparative study

Cite this

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abstract = "1. 1. In the chick biventer cervicis preparation, 4-aminopyridine and 3,4-diaminopyridine selectively augmented indirectly elicited twitches. 2. 2. In the rat hemidiaphragm preparation, both indirectly and directed elicited twitches were augmented. The augmentation was more rapid for indirectly elicited twitches and the twitches became repetitive. 3. 3. The aminopyridines are concluded to facilitate neuromuscular transmission in both species, but increase contractility only in rat. 4. 4. The aminopyridines are suggested to act mainly by inhibiting membrane potassium conductance. Aminopyridine binding sites on the potassium channels may be different in chick and rat muscle. Alternatively, augmentation of contractility in the rat may involve an additional mechanism.",
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A comparison of the effects of aminopyridines on isolated chicken and rat skeletal muscle preparations. / Harvey, A. L.; Marshall, I. G.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 58, No. 2, 01.01.1977, p. 161-165.

Research output: Contribution to journalArticle

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