A comparison of stochastic variation in mixed and unmixed casework and synthetic samples

J. A. Bright, K. McManus, S. Harbison, Peter Gill, J. Buckleton

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Understanding the behaviour of mixed DNA profiles is of paramount importance in forensic DNA analysis. Key parameters are those of heterozygote balance and mixture proportion and its variability. These parameters have been previously explored as a function of the average peak height of the active alleles in single source and mixed samples derived from pristine DNA. Here we report a comparison of this data with data obtained from casework samples. This allows an assessment of the difference in the distribution of heterozygote balance between mixed and single source stains and between casework mixtures and synthetic mixtures constructed from pristine DNA.
Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalForensic Science International: Genetics
Volume6
Issue number2
DOIs
Publication statusPublished - Mar 2012

Keywords

  • mixture proportion
  • mixed DNA profile
  • heterozygote balance
  • STR mixtures

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