A comparison of behaviour following stimulation of the anterior substantia nigra by direct cholinergic agonists and anticholinesterases

Graham C. Parker, Wendy L. Inglis, Philip Winn

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Microinjections of carbachol, a muscarinic cholinergic receptor agonist, into the anterior substantia nigra increase feeding, drinking and sexual behaviour if there is a pre-existing tendency to respond and a low baseline rate of behaviour. The present experiment was undertaken to compare the effects of carbachol with other cholinergic stimulants. Groups of 6-12 satiated rats received 0.5 μl microinjections into the anterior substantia nigra of 0.1-5.0 μg carbachol, 0.1-5.0 μg nicotine, 2.5-10.0 μg eserine, and 1.25-5.0 μg or 0.1-1.0 μg neostigmine (each dissolved in sterile saline) and the effects on feeding, drinking, locomotion, grooming, rearing and sniffing were examined. Carbachol, nicotine and low doses of neostigmine stimulated eating in a dose-dependent manner. The increased feeding following neostigmine was over a shorter time-period than following carbachol or nicotine. Neither carbachol nor nicotine had any significant effect on behaviour other than eating. The higher doses of neostigmine increased the frequency of sniffing and rearing, but not eating, and no dose of eserine had a clear effect on behaviour. These data are discussed in terms of their relationship to the cholinergic input to substantia nigra which excites pars compacta dopamine-containing neurones.

LanguageEnglish
Pages242-248
Number of pages7
JournalPsychopharmacology
Volume112
Issue number2-3
DOIs
Publication statusPublished - 1 Sep 1993

Fingerprint

Cholinergic Agonists
Cholinesterase Inhibitors
Carbachol
Substantia Nigra
Neostigmine
Nicotine
Physostigmine
Microinjections
Feeding Behavior
Cholinergic Agents
Eating
Muscarinic Agonists
Drinking Behavior
Grooming
Dopaminergic Neurons
Cholinergic Receptors
Muscarinic Receptors
Locomotion
Sexual Behavior
Drinking

Keywords

  • behaviour
  • carbachol
  • eating
  • eserine
  • neostigmine
  • nicotine
  • rat
  • substantia nigra

Cite this

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abstract = "Microinjections of carbachol, a muscarinic cholinergic receptor agonist, into the anterior substantia nigra increase feeding, drinking and sexual behaviour if there is a pre-existing tendency to respond and a low baseline rate of behaviour. The present experiment was undertaken to compare the effects of carbachol with other cholinergic stimulants. Groups of 6-12 satiated rats received 0.5 μl microinjections into the anterior substantia nigra of 0.1-5.0 μg carbachol, 0.1-5.0 μg nicotine, 2.5-10.0 μg eserine, and 1.25-5.0 μg or 0.1-1.0 μg neostigmine (each dissolved in sterile saline) and the effects on feeding, drinking, locomotion, grooming, rearing and sniffing were examined. Carbachol, nicotine and low doses of neostigmine stimulated eating in a dose-dependent manner. The increased feeding following neostigmine was over a shorter time-period than following carbachol or nicotine. Neither carbachol nor nicotine had any significant effect on behaviour other than eating. The higher doses of neostigmine increased the frequency of sniffing and rearing, but not eating, and no dose of eserine had a clear effect on behaviour. These data are discussed in terms of their relationship to the cholinergic input to substantia nigra which excites pars compacta dopamine-containing neurones.",
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A comparison of behaviour following stimulation of the anterior substantia nigra by direct cholinergic agonists and anticholinesterases. / Parker, Graham C.; Inglis, Wendy L.; Winn, Philip.

In: Psychopharmacology, Vol. 112, No. 2-3, 01.09.1993, p. 242-248.

Research output: Contribution to journalArticle

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