A CMOS time-resolved fluorescence lifetime analysis micro-system

B.R. Rae, K.R. Muir, Z. Gong, Jonathan McKendry, J.M. Girkin, E. Gu, D. Renshaw, M.D. Dawson, R.K. Henderson

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Abstract

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.
Original languageEnglish
Pages (from-to)9255-9274
Number of pages20
JournalSensors
Volume9
Issue number11
DOIs
Publication statusPublished - 18 Nov 2009

Keywords

  • CMOS
  • single-photon avalanche diodes
  • GaN
  • micro light-emitting diodes (micro-LEDs)
  • fluorescence lifetime
  • micro-system

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    Rae, B. R., Muir, K. R., Gong, Z., McKendry, J., Girkin, J. M., Gu, E., ... Henderson, R. K. (2009). A CMOS time-resolved fluorescence lifetime analysis micro-system. Sensors, 9(11), 9255-9274. https://doi.org/10.3390/s91109255