Projects per year
Abstract
This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino)ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated chemiluminescence (ECL) of the QD/chitosan films upon reaction with H2O2 co-reactant (produced as a by-product of cholesterol oxidase-catalysed oxidation of cholesterol) gave a strong ECL signal at -1.35 V vs. Ag/AgCl. The sensor displayed a linear response over the clinically relevant range (0.25 ≤ [cholesterol] ≤ 5 mM) allowing the rapid detection of cholesterol and providing a platform for future development. Significantly, this NIR emission has been shown to exhibit excellent penetrability through biological samples, and will likely be at the forefront of development in the biosensing and imaging fields for the foreseeable future.
Original language | English |
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Pages (from-to) | 8-14 |
Number of pages | 7 |
Journal | Electrochimica Acta |
Volume | 157 |
Early online date | 17 Jan 2015 |
DOIs | |
Publication status | Published - 1 Mar 2015 |
Keywords
- electrochemiluminescence (ECL)
- biomarkers
- quantum dot
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Projects
- 1 Finished
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ECL Nano-Materials
Dennany, L. & Skabara, P.
European Commission - FP7 - Cooperation only
1/10/10 → 30/09/14
Project: Research
Activities
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3rd Annual Translation & Application of Biosciences: Analytical Biosciences ECM
Lynn Dennany (Member of programme committee)
16 Mar 2016 → 17 Mar 2016Activity: Participating in or organising an event types › Organiser of major conference
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Emerging Analytical Professionals RSC
Lynn Dennany (Invited speaker)
8 Apr 2015 → 10 Apr 2015Activity: Participating in or organising an event types › Participation in conference
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2nd Translation & Application of Biosciences: Analytical Biosciences Early Career Researchers Conference 2013
Lynn Dennany (Member of programme committee)
3 Dec 2013 → 4 Dec 2013Activity: Participating in or organising an event types › Organiser of major conference