Abstract
The group II chaperonin thermosome (THS) from the archaea Thermoplasma acidophilum is reported as nanoreactor for atom-transfer radical polymerization (ATRP). A copper catalyst was entrapped into the THS to confine the polymerization into this protein cage. THS possesses pores that are wide enough to release polymers into solution. The nanoreactor favorably influenced the polymerization of Nisopropyl acrylamide and poly(ethylene glycol)methylether acrylate. Narrowly dispersed polymers with polydispersity indices (PDIs) down to 1.06 were obtained in the protein nanoreactor, while control reactions with a globular protein- catalyst conjugate only yielded polymers with PDIs above 1.84.
| Original language | English |
|---|---|
| Pages (from-to) | 1443-1447 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 53 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 27 Jan 2014 |
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Keywords
- chaperone proteins
- controlled/living radical polymerization
- nanoreactor
- polymerization
- thermosome
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A chaperonin as protein nanoreactor for atom-transfer radical polymerization. / Renggli, Kasper; Nussbaumer, Martin G.; Urbani, Raphael; Pfohl, Thomas; Bruns, Nico.
In: Angewandte Chemie - International Edition, Vol. 53, No. 5, 27.01.2014, p. 1443-1447.Research output: Contribution to journal › Article
TY - JOUR
T1 - A chaperonin as protein nanoreactor for atom-transfer radical polymerization
AU - Renggli, Kasper
AU - Nussbaumer, Martin G.
AU - Urbani, Raphael
AU - Pfohl, Thomas
AU - Bruns, Nico
PY - 2014/1/27
Y1 - 2014/1/27
N2 - The group II chaperonin thermosome (THS) from the archaea Thermoplasma acidophilum is reported as nanoreactor for atom-transfer radical polymerization (ATRP). A copper catalyst was entrapped into the THS to confine the polymerization into this protein cage. THS possesses pores that are wide enough to release polymers into solution. The nanoreactor favorably influenced the polymerization of Nisopropyl acrylamide and poly(ethylene glycol)methylether acrylate. Narrowly dispersed polymers with polydispersity indices (PDIs) down to 1.06 were obtained in the protein nanoreactor, while control reactions with a globular protein- catalyst conjugate only yielded polymers with PDIs above 1.84.
AB - The group II chaperonin thermosome (THS) from the archaea Thermoplasma acidophilum is reported as nanoreactor for atom-transfer radical polymerization (ATRP). A copper catalyst was entrapped into the THS to confine the polymerization into this protein cage. THS possesses pores that are wide enough to release polymers into solution. The nanoreactor favorably influenced the polymerization of Nisopropyl acrylamide and poly(ethylene glycol)methylether acrylate. Narrowly dispersed polymers with polydispersity indices (PDIs) down to 1.06 were obtained in the protein nanoreactor, while control reactions with a globular protein- catalyst conjugate only yielded polymers with PDIs above 1.84.
KW - chaperone proteins
KW - controlled/living radical polymerization
KW - nanoreactor
KW - polymerization
KW - thermosome
UR - http://www.scopus.com/inward/record.url?scp=84892140501&partnerID=8YFLogxK
U2 - 10.1002/anie.201306798
DO - 10.1002/anie.201306798
M3 - Article
VL - 53
SP - 1443
EP - 1447
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 5
ER -