A chaperonin as protein nanoreactor for atom-transfer radical polymerization

Kasper Renggli, Martin G. Nussbaumer, Raphael Urbani, Thomas Pfohl, Nico Bruns

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The group II chaperonin thermosome (THS) from the archaea Thermoplasma acidophilum is reported as nanoreactor for atom-transfer radical polymerization (ATRP). A copper catalyst was entrapped into the THS to confine the polymerization into this protein cage. THS possesses pores that are wide enough to release polymers into solution. The nanoreactor favorably influenced the polymerization of Nisopropyl acrylamide and poly(ethylene glycol)methylether acrylate. Narrowly dispersed polymers with polydispersity indices (PDIs) down to 1.06 were obtained in the protein nanoreactor, while control reactions with a globular protein- catalyst conjugate only yielded polymers with PDIs above 1.84.

Original languageEnglish
Pages (from-to)1443-1447
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number5
DOIs
Publication statusPublished - 27 Jan 2014

Fingerprint

Thermosomes
Nanoreactors
Chaperonins
Atom transfer radical polymerization
Polydispersity
Proteins
Group II Chaperonins
Polymers
Polymerization
Catalysts
Acrylamide
Polymer solutions
Polyethylene glycols
Copper

Keywords

  • chaperone proteins
  • controlled/living radical polymerization
  • nanoreactor
  • polymerization
  • thermosome

Cite this

Renggli, Kasper ; Nussbaumer, Martin G. ; Urbani, Raphael ; Pfohl, Thomas ; Bruns, Nico. / A chaperonin as protein nanoreactor for atom-transfer radical polymerization. In: Angewandte Chemie - International Edition. 2014 ; Vol. 53, No. 5. pp. 1443-1447.
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A chaperonin as protein nanoreactor for atom-transfer radical polymerization. / Renggli, Kasper; Nussbaumer, Martin G.; Urbani, Raphael; Pfohl, Thomas; Bruns, Nico.

In: Angewandte Chemie - International Edition, Vol. 53, No. 5, 27.01.2014, p. 1443-1447.

Research output: Contribution to journalArticle

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