A CFD level-set method for soft tissue growth: theory and fundamental equations

Marcello Lappa

doi:10.1016/j.jbiomech.2004.02.037

A CFD level-set method for soft tissue growth: theory and fundamental equations

Marcello Lappa

Mechanical And Aerospace Engineering

Research output: Contribution to journal › Article

19 Citations (Scopus)

23 Downloads (Pure)

Abstract

A level-set method, specifically conceived for the case of soft organic tissue growth from feeding solutions, is introduced and described in detail. The model can handle the morphological evolution of the organic specimen under the influence of external convection (fluid-dynamics of the bioreactor). The analogies and differences between this technique and a previous volume of fraction method are discussed pointing out advantages and limitations of both formulations.

Original language	English
Pages (from-to)	185-190
Number of pages	6
Journal	Journal of Biomechanics
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.jbiomech.2004.02.037
Publication status	Published - 9 Apr 2004

Keywords

soft tissue growth
bioreactor
tissue engineering
growth kinetics
fluid motion
mathematical models
moving boundary method
morphology evolution
rotating vessel

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10.1016/j.jbiomech.2004.02.037

JBiomech-38(1)-p185-(2004)-AUTHOR_POST-PRINTAccepted author manuscript, 282 KB

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Cite this

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title = "A CFD level-set method for soft tissue growth: theory and fundamental equations",

abstract = "A level-set method, specifically conceived for the case of soft organic tissue growth from feeding solutions, is introduced and described in detail. The model can handle the morphological evolution of the organic specimen under the influence of external convection (fluid-dynamics of the bioreactor). The analogies and differences between this technique and a previous volume of fraction method are discussed pointing out advantages and limitations of both formulations.",

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AB - A level-set method, specifically conceived for the case of soft organic tissue growth from feeding solutions, is introduced and described in detail. The model can handle the morphological evolution of the organic specimen under the influence of external convection (fluid-dynamics of the bioreactor). The analogies and differences between this technique and a previous volume of fraction method are discussed pointing out advantages and limitations of both formulations.

KW - soft tissue growth

KW - bioreactor

KW - tissue engineering

KW - growth kinetics

KW - fluid motion

KW - mathematical models

KW - moving boundary method

KW - morphology evolution

KW - rotating vessel

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