A brief review on recent development of multidisciplinary engineering in fermentation of Saccharomyces cerevisiae

Shiwen Zhuang, Neil Renault, Ian Archer

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Fermentation technology has unprecedented potential to upgrade state-of-art biotechnology and refine the processes used in existing ones, taking into account of complex technical, economic and environmental factors. Given the economic importance and ongoing challenges of biotech sector, multidisciplinary engineering technologies is poised to become an increasingly important tool along with the emergence of modern technology and innovation. This article reviews recent technology advancement in the field of fermentation using Saccharomyces cerevisiae. Interesting research progress has been made by leveraging multiple engineering fields such as electrical engineering, information engineering, electrochemical engineering and new material development, leading to recent development of novel real-time probes (electronic nose technology, analysis of yeast morphology and metabolites, timely control of glucose feed), improved understanding of electro-fermentation (enhanced electronic transfer provision), as well as application of cost-effective and sustainable materials (bioreactor vessel manufactured from textile, and yeast immobilisation support matrix made from abundant natural biomass). To the best of our knowledge, the subject is reviewed for the first time in recent years. Furthermore, this review also constitutes a futuristic S. cerevisiae fermentation process based on the recent advancement discussed.
Original languageEnglish
Pages (from-to)32-41
Number of pages10
JournalJournal of biotechnology
Early online date30 Jul 2021
Publication statusPublished - 20 Sept 2021


  • process analytical technology
  • probes
  • electro-fermentation
  • bioprocess
  • materials


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