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2020

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Alsanafi, M., Kelly, S. L., McNaughton, M., Merrill Jr., A. H., Pyne, N. J. & Pyne, S., 15 Jan 2020, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1865, 4, p. 1-10 10 p., 158631.

Research output: Contribution to journalSpecial issue

p38 Mitogen-Activated Protein Kinases
Kidney
Small Interfering RNA
MAP Kinase Signaling System
Apoptosis
2019
1 Citation (Scopus)

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang, Z., Pyne, S. & Pyne, N. J., 30 Apr 2019, In : Progress in Lipid Research. 74, p. 145-159 15 p.

Research output: Contribution to journalReview article

Ceramides
Adipose Tissue
Type 2 Diabetes Mellitus
Biosynthesis
Tissue
9 Downloads (Pure)

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Blood Pressure
Endothelium
Vasodilation
Controlled Hypotension

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3

Alganga, H., Almabrouk, T. A. M., Katwan, O. J., Daly, C. J., Pyne, S., Pyne, N. J. & Kennedy, S., 31 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access
Vasodilation
Up-Regulation
Arteries
Lysosphingolipid Receptors
Myography
7 Citations (Scopus)

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, Houslay, M. D. & Henderson, D. J. P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.

Research output: Contribution to journalArticle

Open Access
File
Type 4 Cyclic Nucleotide Phosphodiesterase
Phosphoric Diester Hydrolases
Cyclic AMP
Molecules
Autosomal Dominant Polycystic Kidney
1 Downloads (Pure)

Sphingosine 1-phosphate turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Pyne, N. J. & Pyne, S., 16 Sep 2019, In : IUPHAR/BPS Guide to Pharmacology CITE. 2019, 4, 3 p.

Research output: Contribution to journalShort survey

Open Access
File
Databases
Pharmacology
Sphingosine
Sphingolipidoses
Cell Proliferation
3 Citations (Scopus)

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. J. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Protein Isoforms
Ligands
Lipids
Sphingosine
Foot
2018
7 Downloads (Pure)

Cellular Signalling – Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz

Shukla, A. K. & Pyne, N. J., 1 Jan 2018, In : Cellular Signalling. 41, p. 1 1 p.

Research output: Contribution to journalEditorial

Open Access
File
3 Citations (Scopus)
8 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Breast Neoplasms
Neoplasms
Medicine
Survival
5 Citations (Scopus)
9 Downloads (Pure)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide
19 Citations (Scopus)
82 Downloads (Pure)

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., 12 May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Lysosphingolipid Receptors
Neoplasms
Fibroblasts
TNF Receptor-Associated Factor 2
Phosphorylation
10 Citations (Scopus)
20 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms
2017
3 Citations (Scopus)
19 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Autoimmune Experimental Encephalomyelitis
Interleukin-1
Inflammation
Sphingosine
21 Citations (Scopus)
170 Downloads (Pure)

Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, N. J. & Pyne, S., 23 Feb 2017, In : Molecules. 22, 3, p. 1-18 18 p., 344.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Arrestin
GTP-Binding Proteins
phosphates
Cells
5 Citations (Scopus)
8 Downloads (Pure)

Sphingosine kinase1: a potential therapeutic target in pulmonary arterial hypertension?

Pyne, N. J. & Pyne, S., 30 Sep 2017, In : Trends in Molecular Medicine. 23, 9, p. 786-798 13 p.

Research output: Contribution to journalComment/debate

Open Access
File
Sphingosine
Pulmonary Hypertension
Therapeutics
Lung
Enzymes
1 Citation (Scopus)
22 Downloads (Pure)

Sphingosine kinase 2 and multiple myeloma

Pyne, N. J. & Pyne, S., 25 Apr 2017, In : Oncotarget. 8, 24, p. 43596-43597 2 p., 17420.

Research output: Contribution to journalArticle

Open Access
File
Endoplasmic Reticulum Stress
Multiple Myeloma
sphingosine kinase
Bortezomib
8 Citations (Scopus)
16 Downloads (Pure)

Sphingosine kinase 2 in autoimmune/inflammatory disease and development of sphingosine kinase 2 inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., 31 Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Autoimmune Diseases
Histone Deacetylase 2
Histone Deacetylase 1
Th17 Cells
Retinoids
2016
60 Downloads (Pure)
Open Access
File
Sphingolipids
Sterols
Phospholipids
Lipids
Research
2 Citations (Scopus)
25 Downloads (Pure)

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis

Boomkamp, S. D., Byun, H-S., Ubhi, S., Jiang, H-R., Pyne, S., Bittman, R. & Pyne, N. J., 1 Jan 2016, In : Chemistry and Physics of Lipids. 194, p. 2-11 10 p.

Research output: Contribution to journalArticle

Open Access
File
Glyceryl Ethers
Sphingosine
Autoimmune Experimental Encephalomyelitis
Interleukin-1
Inflammasomes
14 Citations (Scopus)
64 Downloads (Pure)

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N., 1 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pulmonary Hypertension
Right Ventricular Hypertrophy
Cardiac Myocytes
Lung
Oxidants
38 Citations (Scopus)
244 Downloads (Pure)
Open Access
File
Androgens
Prostatic Neoplasms
Growth
Fenretinide
Small Interfering RNA
77 Citations (Scopus)
84 Downloads (Pure)

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H-R., Ubhi, S. K. & Pyne, S., 1 Jan 2016, In : Advances in Biological Regulation. 60, p. 151-159 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Sphingosine
Inflammation
Breast Neoplasms
67 Citations (Scopus)
122 Downloads (Pure)

Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., 1 Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalLiterature review

Open Access
File
Health
Protein Isoforms
Lipids
Cardiovascular system
Neurology
31 Citations (Scopus)
41 Downloads (Pure)

Sphingosine kinases: emerging structure function insights

Adams, D. R., Pyne, S. & Pyne, N. J., 1 May 2016, In : Trends in Biochemical Sciences . 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingosine
Dimerization
Phospholipids
Cell Survival
Phosphotransferases
14 Citations (Scopus)
198 Downloads (Pure)

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

Evangelisti, C., Evangelisti, C., Buontempo, F., Lonetti, A., Orsini, E., Chiarini, F., Barata, J. T., Pyne, S., Pyne, N. J. & Martelli, A. M., 1 Nov 2016, In : Leukemia. 30, p. 2142–2151 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Hematologic Neoplasms
Sphingosine
Sphingolipids
Ceramides
Neoplasms