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2020

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Alsanafi, M., Kelly, S. L., McNaughton, M., Merrill Jr., A. H., Pyne, N. J. & Pyne, S., 15 Jan 2020, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1865, 4, p. 1-10 10 p., 158631.

Research output: Contribution to journalSpecial issue

p38 Mitogen-Activated Protein Kinases
Kidney
Small Interfering RNA
MAP Kinase Signaling System
Apoptosis
2019
1 Citation (Scopus)

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang, Z., Pyne, S. & Pyne, N. J., 30 Apr 2019, In : Progress in Lipid Research. 74, p. 145-159 15 p.

Research output: Contribution to journalReview article

Ceramides
Adipose Tissue
Type 2 Diabetes Mellitus
Biosynthesis
Tissue
9 Downloads (Pure)

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Blood Pressure
Endothelium
Vasodilation
Controlled Hypotension

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3

Alganga, H., Almabrouk, T. A. M., Katwan, O. J., Daly, C. J., Pyne, S., Pyne, N. J. & Kennedy, S., 31 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access
Vasodilation
Up-Regulation
Arteries
Lysosphingolipid Receptors
Myography
7 Citations (Scopus)

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, Houslay, M. D. & Henderson, D. J. P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.

Research output: Contribution to journalArticle

Open Access
File
Type 4 Cyclic Nucleotide Phosphodiesterase
Phosphoric Diester Hydrolases
Cyclic AMP
Molecules
Autosomal Dominant Polycystic Kidney
1 Downloads (Pure)

Sphingosine 1-phosphate turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Pyne, N. J. & Pyne, S., 16 Sep 2019, In : IUPHAR/BPS Guide to Pharmacology CITE. 2019, 4, 3 p.

Research output: Contribution to journalShort survey

Open Access
File
Databases
Pharmacology
Sphingosine
Sphingolipidoses
Cell Proliferation
2 Citations (Scopus)

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. J. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Protein Isoforms
Ligands
Lipids
Sphingosine
Foot
2018
7 Downloads (Pure)

Cellular Signalling – Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz

Shukla, A. K. & Pyne, N. J., 1 Jan 2018, In : Cellular Signalling. 41, p. 1 1 p.

Research output: Contribution to journalEditorial

Open Access
File
3 Citations (Scopus)
8 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Breast Neoplasms
Neoplasms
Medicine
Survival
5 Citations (Scopus)
9 Downloads (Pure)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide
18 Citations (Scopus)
81 Downloads (Pure)

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., 12 May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Lysosphingolipid Receptors
Neoplasms
Fibroblasts
TNF Receptor-Associated Factor 2
Phosphorylation
9 Citations (Scopus)
20 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms
2017
3 Citations (Scopus)
19 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Autoimmune Experimental Encephalomyelitis
Interleukin-1
Inflammation
Sphingosine
21 Citations (Scopus)
170 Downloads (Pure)

Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, N. J. & Pyne, S., 23 Feb 2017, In : Molecules. 22, 3, p. 1-18 18 p., 344.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Arrestin
GTP-Binding Proteins
phosphates
Cells
4 Citations (Scopus)
8 Downloads (Pure)

Sphingosine kinase1: a potential therapeutic target in pulmonary arterial hypertension?

Pyne, N. J. & Pyne, S., 30 Sep 2017, In : Trends in Molecular Medicine. 23, 9, p. 786-798 13 p.

Research output: Contribution to journalComment/debate

Open Access
File
Sphingosine
Pulmonary Hypertension
Therapeutics
Lung
Enzymes
1 Citation (Scopus)
22 Downloads (Pure)

Sphingosine kinase 2 and multiple myeloma

Pyne, N. J. & Pyne, S., 25 Apr 2017, In : Oncotarget. 8, 24, p. 43596-43597 2 p., 17420.

Research output: Contribution to journalArticle

Open Access
File
Endoplasmic Reticulum Stress
Multiple Myeloma
sphingosine kinase
Bortezomib
8 Citations (Scopus)
16 Downloads (Pure)

Sphingosine kinase 2 in autoimmune/inflammatory disease and development of sphingosine kinase 2 inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., 31 Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Autoimmune Diseases
Histone Deacetylase 2
Histone Deacetylase 1
Th17 Cells
Retinoids
2016
60 Downloads (Pure)
Open Access
File
Sphingolipids
Sterols
Phospholipids
Lipids
Research
2 Citations (Scopus)
25 Downloads (Pure)

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis

Boomkamp, S. D., Byun, H-S., Ubhi, S., Jiang, H-R., Pyne, S., Bittman, R. & Pyne, N. J., 1 Jan 2016, In : Chemistry and Physics of Lipids. 194, p. 2-11 10 p.

Research output: Contribution to journalArticle

Open Access
File
Glyceryl Ethers
Sphingosine
Autoimmune Experimental Encephalomyelitis
Interleukin-1
Inflammasomes
14 Citations (Scopus)
64 Downloads (Pure)

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N., 1 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pulmonary Hypertension
Right Ventricular Hypertrophy
Cardiac Myocytes
Lung
Oxidants
38 Citations (Scopus)
244 Downloads (Pure)
Open Access
File
Androgens
Prostatic Neoplasms
Growth
Fenretinide
Small Interfering RNA
77 Citations (Scopus)
84 Downloads (Pure)

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H-R., Ubhi, S. K. & Pyne, S., 1 Jan 2016, In : Advances in Biological Regulation. 60, p. 151-159 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Sphingosine
Inflammation
Breast Neoplasms
67 Citations (Scopus)
121 Downloads (Pure)

Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., 1 Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalLiterature review

Open Access
File
Health
Protein Isoforms
Lipids
Cardiovascular system
Neurology
30 Citations (Scopus)
41 Downloads (Pure)

Sphingosine kinases: emerging structure function insights

Adams, D. R., Pyne, S. & Pyne, N. J., 1 May 2016, In : Trends in Biochemical Sciences . 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingosine
Dimerization
Phospholipids
Cell Survival
Phosphotransferases
14 Citations (Scopus)
198 Downloads (Pure)

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

Evangelisti, C., Evangelisti, C., Buontempo, F., Lonetti, A., Orsini, E., Chiarini, F., Barata, J. T., Pyne, S., Pyne, N. J. & Martelli, A. M., 1 Nov 2016, In : Leukemia. 30, p. 2142–2151 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Hematologic Neoplasms
Sphingosine
Sphingolipids
Ceramides
Neoplasms
2015
80 Downloads (Pure)

The life and work of Dr Robert Bittman (1942-2014)

Pyne, N. J. & Kolesnick, R. N., Jun 2015, In : Biological Chemistry. 396, 6-7, p. 827-830 4 p.

Research output: Contribution to journalComment/debate

Open Access
File
Biophysics
Lipids
Sphingolipids
Membrane Lipids
Phospholipids
2014
28 Citations (Scopus)
119 Downloads (Pure)

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Evangelisti, C., Evangelisti, C., Teti, G., Chiarini, F., Falconi, M., Melchionda, F., Pession, A., Bertaina, A., Locatelli, F., McCubrey, JA., Baek, DJ., Bittman, R., Pyne, S., Pyne, N. & Martelli, AM., 2014, In : Oncotarget. 5, 17, p. 7886-7901 16 p.

Research output: Contribution to journalArticle

Open Access
File
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Unfolded Protein Response
Autophagy
Apoptosis
Therapeutics
42 Citations (Scopus)
90 Downloads (Pure)

Crystal structure of sphingosine kinase 1 with PF-543

Wang, J., Knapp, S., Pyne, N., Pyne, S. & Elkins, J., 27 Dec 2014, In : Medicinal Chemistry Letters. 5, 12, p. 1329-1333 5 p.

Research output: Contribution to journalArticle

Open Access
File
Crystal structure
Sphingosine
Conformations
Substrates
PF-543
8 Citations (Scopus)
513 Downloads (Pure)

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

Lim, K. G., Gray, A. I., Anthony, N. G., MacKay, S. P., Pyne, S. & Pyne, N. J., 25 Oct 2014, In : Archives of Toxicology. 88, 12, p. 2213-2232 20 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingolipids
Oligomers
Metabolism
Modulation
Biological Availability
138 Downloads (Pure)

Selective inhibitors and allosteric activators of sphingosine kinase

Bittman, R., Pyne, N., Pyne, S., Baek, D. J., Liu, Z. & Byun, H-S., 7 Aug 2014, IPC No. C07D401/04, Patent No. PCT/GB2014/050264, Priority date 31 Jan 2013

Research output: Patent

Sphingosine
Pulmonary Hypertension
Fibrosis
sphingosine kinase
sphingosine 1-phosphate
9 Citations (Scopus)
79 Downloads (Pure)

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

Pyne, N. J. & Pyne, S., 26 Jun 2014, In : Oncogene. 33, 26, p. 3361-3363 3 p.

Research output: Contribution to journalArticle

Open Access
File
Myofibroblasts
Melanoma
Fibroblasts
Neoplasm Metastasis
Lysosphingolipid Receptors
18 Citations (Scopus)
87 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Estrogen Receptors
Breast Neoplasms
Growth
Small Interfering RNA
38 Citations (Scopus)
171 Downloads (Pure)

The role of sphingosine 1-phosphate in inflammation and cancer

Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S., Jan 2014, In : Advances in Biological Regulation. 54, p. 121-129 9 p.

Research output: Contribution to journalLiterature review

Open Access
File
Inflammation
Neoplasms
Lysosphingolipid Receptors
Sphingolipids
Knockout Mice
2013
25 Citations (Scopus)
Lysosphingolipid Receptors
Estrogen Receptors
Breast Neoplasms
Proteins
Biomarkers
13 Citations (Scopus)

New perspectives on the role of sphingosine 1-phosphate in cancer

Pyne, S. & Pyne, N., 31 Mar 2013, Sphingolipids in Disease. Gulbins, E. & Petrache, I. (eds.). Vienna: Springer-Verlag, p. 55-71 17 p. (Handbook of experimental pharmacology ; no. 216).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Neoplasms
sphingosine 1-phosphate
sphingosine kinase
Therapeutics
sphingosine 1-phosphate lyase (aldolase)
41 Citations (Scopus)
90 Downloads (Pure)
Open Access
File
Sphingosine
Isoenzymes
Smooth Muscle Myocytes
Muscle
Cells
40 Citations (Scopus)

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Rutherford, C., Childs, S., Ohotski, J., McGlynn, L., Riddick, M., MacFarlane, S., Tasker, D., Pyne, S., Pyne, N. J., Edwards, J. & Palmer, T. M., 21 Nov 2013, In : Cell Death and Disease. 4, 15 p., e927.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Extracellular Signal-Regulated MAP Kinases
Phosphatidylinositol 3-Kinases
Caspase 3
Protein Kinase C
31 Citations (Scopus)

Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis

Pyne, N., Dubois, G. & Pyne, S., Jan 2013, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1831, 1, p. 228-238 10 p.

Research output: Contribution to journalSpecial issue

Fibrosis
Lysophosphatidic Acid Receptors
Myofibroblasts
Macular Degeneration
Antibodies
22 Citations (Scopus)

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Pyne, S. & Pyne, N., 14 Jan 2013, In : Cancer Cell. 23, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
NF-kappa B
Colonic Neoplasms
Interleukin-6
Inflammation
30 Citations (Scopus)
164 Downloads (Pure)

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors

Baek, D. J., MacRitchie, N., Anthony, N. G., Mackay, S. P., Pyne, S., Pyne, N. J. & Bittman, R., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9310-9327 18 p.

Research output: Contribution to journalArticle

Open Access
File
Structure-Activity Relationship
Protein Isoforms
Phosphorylation
Pharmacology
Lipids
20 Citations (Scopus)

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Liu, Z., MacRitchie, N., Pyne, S., Pyne, N. J. & Bittman, R., 1 May 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2503-2510 8 p.

Research output: Contribution to journalArticle

Allosteric Site
Neoplasms
Structure-Activity Relationship
Scaffolds
Cells
33 Citations (Scopus)

Synthesis of selective inhibitors of sphingosine kinase 1

Baek, D. J., MacRitchie, N., Pyne, N., Pyne, S. & Bittman, R., 2013, In : Chemical Communications (London). 4 p.

Research output: Contribution to journalArticle

Protein Isoforms
Sphingosine
Muscle
Cells
Degradation
134 Citations (Scopus)

The Concise Guide to PHARMACOLOGY 2013/14: overview

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., McGrath, J. C., Catterall, W. A., Spedding, M., Peters, J. A., Harmar, A. J., Abul-Hasn, N., Anderson, C. M., Anderson, C. M. H., Araiksinen, M. S., Arita, M., Arthofer, E., Barker, E. L., Barratt, C., Barnes, N. M., Bathgate, R. & 31 others, Beart, P. M., Belelli, D., Bennett, A. J., Birdsall, N. J. M., Boison, D., Bonner, T. I., Brailsford, L., Bröer, S., Brown, P., Calo, G., Carter, W. G., Catterall, W. A., Chan, S. L. F., Chao, M. V., Chiang, N., Christopoulos, A., Chun, J. J., Cidlowski, J., Clapham, D. E., Cockcroft, S., Connor, M. A., Cox, H. M., Cuthbert, A., Dautzenberg, F. M., Davenport, A. P., Dawson, P. A., Jones, R. L., Kennedy, C., Pyne, N. J., Pyne, S. & CGTP Collaborators, Dec 2013, In : British Journal of Pharmacology. 170, 8, p. 1449-58 10 p.

Research output: Contribution to journalSpecial issue

Pharmacology
Terminology
Pharmaceutical Preparations
Databases
Ligands
2 Citations (Scopus)

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism

Gibriel, A., Tate, R., Yu, Y., Rawson-Lax, E., Hammer, HM., Tettey, J. N. A., Pyne, N. & Converse, C., 15 Feb 2013, In : Gene. 515, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Glutamic Acid
Exons
Mutation
Proteins
62 Downloads (Pure)

The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells

Tonelli, F., Alossaimi, M., Natarajan, V., Gorshkova, I., Berdyshev, E., Bittman, R., Watson, D. G., Pyne, S. & Pyne, N. J., 2013, In : Biomolecules. 3, 2, p. 316-333 18 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolome
Androgens
Ceramides
Prostatic Neoplasms
Cells
31 Citations (Scopus)

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells

Watson, D. G., Tonelli, F., Al Osaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N. J. & Pyne, S., Apr 2013, In : Cellular Signalling. 25, 4, p. 1011-1017 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Sphingosine
Protein Isoforms
Oxidative Stress
Apoptosis
15 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Thiazoles
Androgen Receptors
Oxidative Stress
Prostatic Neoplasms
sphingosine kinase
2012
45 Citations (Scopus)

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

Ohotski, J., Long, J., Orange, C., Elsberger, B., Mallon, E., Doughty, J., Pyne, S., Pyne, N. & Edwards, J., 10 Apr 2012, In : British Journal of Cancer. 106, 8, p. 1453-1459 7 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Estrogen Receptors
Breast Neoplasms
Survival
Neoplasms
26 Citations (Scopus)

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b

Lim, K. G., Tonelli, F. R., Berdyshev, E., Gorshkova, I., Leclercq, T., Pitson, S. M., Bittman, R., Pyne, S. & Pyne, N., Sep 2012, In : International Journal of Biochemistry and Cell Biology. 44, 9, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Cells
Sphingosine
Kinetics
Adenosine Triphosphate

Lysophospholipid receptor signalling platforms: the receptor tyrosine kinase-G-protein coupled receptor signaling complex

Pyne, N. & Pyne, S., Nov 2012, Lysophospholipid Receptors: Signaling and Biochemistry. Chun, J. (ed.). Chichester: John Wiley & Sons Inc., p. 85-102 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Lysophospholipid Receptors
Receptor Protein-Tyrosine Kinases
G-Protein-Coupled Receptors