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2018
11 Downloads (Pure)
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Cobalt
Rats
Fibroblasts
Proteins
Metals
2017

CoCl2 induced cardiotoxicity associated with CoCr alloy orthopaedic implants

Laovitthayanggoon, S., Grant, M. H., Henderson, C. J., Tate, R. J. & Currie, S., 1 Apr 2017, In : Heart . 103, S2, p. A4 1 p., 9.

Research output: Contribution to journalMeeting abstract

Orthopedics
Fibroblasts
Metals
3T3 Cells
Ions
2 Citations (Scopus)
8 Downloads (Pure)

Development and mechanical characterisation of self-compressed collagen gels

Andriakopoulou, C. E., Zadpoor, A. A., Grant, M. H. & Riches, P. E., 28 Nov 2017, In : Materials Science and Engineering: C . 17 p.

Research output: Contribution to journalArticle

Open Access
File
collagens
Collagen
Gels
gels
mechanical properties
15 Citations (Scopus)
68 Downloads (Pure)

Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications

Nelson, L. J., Morgan, K., Treskes, P., Samuel, K., Henderson, C. J., LeBled, C., Homer, N., Grant, M. H., Hayes, P. C. & Plevris, J. N., 31 Jan 2017, In : Basic and Clinical Pharmacology and Toxicology . 120, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

Open Access
File
Hep G2 Cells
Metabolism
Hepatocytes
Phenotype
Liver
19 Downloads (Pure)

In vitro effects of cobalt ions on CNS derived cell lines

Gomez Arnaiz, S., Tate, R., Currie, S. & Grant, M., 3 Apr 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Cobalt
Cells
Ions
Assays
Metals
38 Downloads (Pure)

In vivo and in vitro toxicity of cobalt in the heart

Laovitthayanggoon, S., Henderson, C. J., Tate, R. J., Currie, S., McCluskey, C., Macdonald, M. & Grant, M. H., 3 Apr 2017. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Fibroblasts
Toxicity
Cobalt
Rats
Bearings (structural)
2016
3 Citations (Scopus)
84 Downloads (Pure)
Open Access
File
endoscopes
Endoscopy
Light sources
safety
light sources
7 Citations (Scopus)
32 Downloads (Pure)

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
gemcitabine
Binders
Lung Neoplasms
Biological Products
Early Detection of Cancer
12 Citations (Scopus)
40 Downloads (Pure)

Bioinspired silica offers a novel, green and biocompatible alternative to traditional drug delivery systems

Davidson, S., Lamprou, D. A., Urquhart, A. J., Grant, M. & Patwardhan, S. V., 24 Aug 2016, In : ACS Biomaterials Science & Engineering. 2, 9, p. 1493–1503 11 p.

Research output: Contribution to journalArticle

Open Access
File
Silicon Dioxide
Silica
Pharmaceutical Preparations
Hazardous Substances
Ibuprofen
63 Downloads (Pure)

Cobalt cardiotoxicity - effects on the contractile and non-contractile cells of the heart

Laovitthayanggoon, S., Tate, R., Currie, S. & Grant, M. H., 30 Apr 2016, In : FASEB Journal. 30, 1, 1 p., 178.7.

Research output: Contribution to journalMeeting abstract

Open Access
File
Fibroblasts
Cobalt
Isoproterenol
Cells
Gentian Violet

Comparison of the metabolism of mephedrone in cultured and in freshly isolated primary rat hepatocytes

Alanazi, I., Grant, M. H., Watson, D. & Henderson, C., 31 Dec 2016, In : Applied in Vitro Toxicology . 2, 4, p. 241-241 1 p.

Research output: Contribution to journalMeeting abstract

Open Access
Metabolites
Metabolism
Rats
Hepatocytes
Street Drugs

Considerations for the technical development of 405nm light for decontamination applications in arthroplasty surgery.

Ramakrishnan, P., MacLean, M., Anderson, J., MacGregor, S., Clarke, J., Meek, R. M. D. & Grant, M., 5 Sep 2016.

Research output: Contribution to conferenceAbstract

Decontamination
Arthroplasty
Lighting
Light
Infection Control
34 Citations (Scopus)
89 Downloads (Pure)
Open Access
File
Reactive Oxygen Species
Cells
Light
Oxygen
Oxidative stress
Decontamination
Arthroplasty
Technology
Light
Cell Survival
38 Downloads (Pure)

Identification of novel metabolic pathways of sitagliptin (STG) by LC/MS and LC/MS2 after incubations with rat hepatcoytes

Khreit, O. IG., Grant, H. M., Henderson, C., Watson, D. G. & Sutcliffe, O. B., 30 Dec 2016, In : Drug Metabolism and Disposition. 7, 4, 7 p., 1000220.

Research output: Contribution to journalArticle

Open Access
File
Metabolic Networks and Pathways
Glucuronides
Sulfates
Ions
Hydroxylation
30 Downloads (Pure)
Open Access
File
Replacement Arthroplasties
3T3 Cells
Fibroblasts
Cobalt
Toxicity
17 Citations (Scopus)
77 Downloads (Pure)
Open Access
File
Salt-Tolerance
Staphylococcus aureus
Light
Membranes
Escherichia coli
2015

405 nm light technology shows potential for patient safe decontamination during orthopaedic surgery

Ramakrishnan, P., MacLean, M., MacGregor, S., Anderson, J. & Grant, MH., 31 Jul 2015, In : European Cells and Materials. 30 , S2, p. 25 1 p.

Research output: Contribution to journalMeeting abstract

Decontamination
Orthopedics
Arthroplasty
Surgery
Technology

Bio-inspired silica nanoparticles as drug delivery vehicles

Davidson, S., Grant, M., Lamprou, D. & Patwardhan, S., 29 Jul 2015. 1 p.

Research output: Contribution to conferenceAbstract

22 Citations (Scopus)
132 Downloads (Pure)

Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells

Posada, O. M., Tate, R. J. & Grant, M. H., Mar 2015, In : Toxicology in Vitro. 29, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

Open Access
File
U937 Cells
Debris
Hip
Monocytes
Metals
12 Citations (Scopus)
98 Downloads (Pure)
Open Access
File
Arthroplasty
Lower Extremity
Light
Dosimetry
Bacteria

Influence of mechanical properties of collagen on the metabolic activity of sandwich-cultured human hepatocyes

Agbekoh, P., Henderson, C., Riches, P. & Grant, M., 25 Jun 2015, p. 85-86. 2 p.

Research output: Contribution to conferenceAbstract

13 Citations (Scopus)
69 Downloads (Pure)
Open Access
File
Cobalt alloys
Chromium alloys
Debris
Gene expression
Toxicity

LC-MS analysis of the metabolism of the dietary constituent hesperidin by rat hepatocytes.

Omar, K. M. K., Grant, M., Henderson, C. & Watson, D., 25 Jun 2015, p. 98. 1 p.

Research output: Contribution to conferenceAbstract

Metabolomics as a tool to investigate mephadrone as a drug of abuse in rat hepatocytes.

Alwashih, M., Watson, D., Grant, M. & Henderson, C., 25 Jun 2015, p. 93-94. 2 p.

Research output: Contribution to conferenceAbstract

Microfluidics liposome formulation and investigation of liposome-cell interactions by atomic force microscopy

Kemp, O., Grant, M. & Lamprou, D., 29 Jul 2015. 1 p.

Research output: Contribution to conferenceAbstract

20 Downloads (Pure)

The effects of decellularisation on the mechanical properties of bone, and subsequent recellularisation of the samples.

Mohd Riduan Bin Mohamad, M., Riches, P. & Grant, M. H., 12 Oct 2015. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Bone
Bone and Bones
Mechanical properties
Elastic Modulus
Porosity
20 Citations (Scopus)
106 Downloads (Pure)
Open Access
File
Lymphocytes
Chromium
Cobalt
Debris
Nanoparticles
2014

Atomic force microscopy (AFM) analysis of nanocarrier–cell interaction

Kemp, O., Grant, H. & Lamprou, D., 10 Sep 2014, In : Toxicology Letters. 229, Supplement, p. S67 1 p., P-1.86.

Research output: Contribution to journalMeeting abstract

17 Citations (Scopus)
101 Downloads (Pure)

Bioinspired silica as drug delivery systems and their biocompatibility

Steven, C. R., Busby, G., Mather, C., Tariq, B., Briuglia, M. L., Lamprou, D., Urquhart, A., Grant, M. & Patwardhan, S., 2014, In : Journal of Materials Chemistry B. 2, 31, p. 5028-5042 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Delivery Systems
Biocompatibility
Silicon Dioxide
Silica
Pharmaceutical Preparations
20 Citations (Scopus)
149 Downloads (Pure)
Open Access
File
Chromium Alloys
U937 Cells
Chromium
Cobalt
Toxicology

Collagen hydrogel matrices for primary hepatocyte culture

Agbekoh, P. E., Henderson, C., Riches, P. E. & Grant, M. H., 10 Sep 2014, In : Toxicology Letters. 229, Supplement, p. S141-S142 2 p., P-2.151.

Research output: Contribution to journalMeeting abstract

14 Citations (Scopus)
243 Downloads (Pure)
Open Access
File
osteoblasts
orthopedics
decontamination
pathogens
Decontamination
46 Downloads (Pure)

Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices

Agbekoh, P. E., Henderson, C., Riches, P. E. & Grant, M. H., Nov 2014, In : European Cells and Materials. 28, S.4, p. 77 1 p.

Research output: Contribution to journalMeeting abstract

Open Access
File
Collagen
Rats
Hepatocytes
Gels
Mechanical properties
85 Downloads (Pure)

Human hepatic HepaRG cells maintain high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells used in drug pharmacology applications

Nelson, L. J., Treskes, P., Henderson, C. J., Homer, N., Morgan, K., LeBled, C., Grant, M. H. & Plevris, J. N., 30 Apr 2014, In : Journal of Hepatology. 60, 1 Supplement, p. S176-S177 2 p.

Research output: Contribution to journalMeeting abstract

File
Hep G2 Cells
Hepatocytes
Phenacetin
Cytochrome P-450 CYP1A2
Pharmacology
81 Downloads (Pure)

Optimising 405 nm HINS light technology for patient safe decontamination during arthroplasty surgery.

Ramakrishnan, P., MacLean, M., MacGregor, S., Anderson, J. & Grant, M. H., Nov 2014, In : European Cells and Materials. 28, S.4, p. 36 1 p.

Research output: Contribution to journalMeeting abstract

Open Access
File
Arthroplasty
Decontamination
Surgery
Technology
Light
9 Citations (Scopus)
Rats
Hepatocytes
Membranes
Binding Sites
Pharmaceutical Preparations
ferulic acid
Metabolites
Glutathione
Rats
Hepatocytes
3 Citations (Scopus)
57 Downloads (Pure)

The complex degradation and metabolism of quercetin in rat hepatocyte incubations

Omar, K., Grant, M. H., Henderson, C. & Watson, D. G., 1 Dec 2014, In : Xenobiotica. 44, 12, p. 1074-1082 9 p.

Research output: Contribution to journalArticle

Open Access
File
Quercetin
Metabolism
Rats
Hepatocytes
Metabolites
Endoscopy
Light sources
Adhesion
Contact angle
Fourier transform infrared spectroscopy

The effects of decellularisation on the mechanical properties of bone

Mohamad, M. R., Riches, P. & Grant, M. H., Nov 2014, In : European Cells and Materials. 28, S.4, p. 72 1 p.

Research output: Contribution to journalMeeting abstract

Bone
Bone and Bones
Mechanical properties
Scaffolds
Mechanical Phenomena
2013
25 Citations (Scopus)
72 Downloads (Pure)

405 nm light exposure of osteoblasts and inactivation of bacterial isolates from arthroplasty patients: potential for new disinfection applications?

McDonald, R., Gupta, S., MacLean, M., Ramakrishnan, P., Anderson, J., MacGregor, S., Meek, D. & Grant, M., 7 Mar 2013, In : European Cells and Materials. 25, March, p. 204-214 11 p.

Research output: Contribution to journalArticle

Open Access
File
Arthroplasty
Disinfection
Osteoblasts
Light
Surgery
U937 Cells
Chromium
Cobalt
Toxicology
Monocytes

Co–Cr wear products derived from metal-on-metal articulations induce apoptosis on monocyte-like U937 cells

Posada Estefan, O. M., Grant, H. & Tate, R. J., Aug 2013, In : Toxicology Letters. 28, Suppl, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

U937 Cells
Cell death
Cobalt
Monocytes
Debris
14 Citations (Scopus)
Capillary tubes
Hydrogel
Endothelial cells
Nanofibers
Hydrogels
14 Citations (Scopus)
536 Downloads (Pure)

Confined compression of collagen hydrogels

Busby, G. A., Grant, M. H., MacKay, S. P. & Riches, P. E., 22 Feb 2013, In : Journal of Biomechanics. 46, 4, p. 837-840 4 p.

Research output: Contribution to journalArticle

File
Hydrogels
Collagen
Permeability
Tissue Engineering
Scaffolds (biology)
30 Citations (Scopus)
Metabolic Networks and Pathways
Liver
Rats
Hepatocytes
monomethylpropion

The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

Busby, G., Riches, P., Grant, M. & MacKay, S., Aug 2013, In : International Journal of Artificial Organs. 36, 8, p. 567 O106.

Research output: Contribution to journalMeeting abstract

Collagen
Gels
Mechanical properties
Cell proliferation
Tissue Engineering
1 Citation (Scopus)

The influence of the choice of digestion enzyme used to prepare rat hepatocytes on xenobiotic uptake and efflux

Sinclair, J. A., Henderson, C., Tettey, J. N. A. & Grant, M. H., Feb 2013, In : Toxicology in Vitro. 27, 1, p. 451-457 7 p.

Research output: Contribution to journalArticle

Collagenases
Xenobiotics
Rats
Digestion
Hepatocytes