Find Research Outputs

Search concepts
Selected filters
2020

Metabolomic tools used in marine natural product drug discovery

Stuart, K. A., Welsh, K., Walker, M. C. & Edrada-Ebel, R., 6 Feb 2020, In : Expert Opinion on Drug Discovery.

Research output: Contribution to journalReview article

Metabolomics
Drug Discovery
Biological Products
trabectedin
dolastatin 10
2019
5 Citations (Scopus)
9 Downloads (Pure)

Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta)

Raheem, D. J., Tawfike, A. F., Abdelmohsen, U. R., Edrada-Ebel, R. & Fitzsimmons-Thoss, V., 22 Feb 2019, In : Scientific Reports. 9, 13 p., 2547 .

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Saponins
Glycosides
Metabolites
Molecular Weight

Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt

Sebak, M., Saafan, A. E., AbdelGhani, S., Bakeer, W., El-Gendy, A. O., Castaño Espriu, L., Duncan, K. & Edrada-Ebel, R., 30 Dec 2019, In : PLOS One. 14, 12, 29 p., e0226959.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Actinobacteria
Bioassay
Egypt
metabolomics
1 Downloads (Pure)

Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study

do Nascimento, T. G., dos Santos Arruda, R. E., da Cruz Almeida, E. T., dos Santos Oliveira, J. M., Basílio-Júnior, I. D., Celerino de Moraes Porto, I. C., Rodrigues Sabino, A., Tonholo, J., Gray, A., Edrada Ebel, R., Clements, C., Zhang, T. & Watson, D. G., 4 Dec 2019, In : Scientific Reports. 9, p. 1-16 16 p., 18293.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Antioxidants
Flavonoids
Droughts
Climate
1 Citation (Scopus)
9 Downloads (Pure)

Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis

Siheri, W., Ebiloma, G. U., Igoli, J. O., Gray, A. I., Biddau, M., Akrachalanont, P., Samya Sh M D Alenezi, S., Alwashih, M. A., Edrada Ebel, R., Müller, S., Lawrence, C. E., Fearnley, J., Watson, D. G. & De Koning, H. P., 15 Mar 2019, In : Molecules. 24, 6, 12 p., 1041.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trichinella spiralis
Caenorhabditis elegans
Plasmodium falciparum
isolation
6 Citations (Scopus)
3 Downloads (Pure)
Open Access
File
Endophytes
Metabolomics
Trypanosomiasis
Aspergillus
Metabolites
3 Citations (Scopus)

Metabolomics-guided isolation of anti-trypanosomal compounds from endophytic fungi of the mangrove plant Avicennia lanata

Mazlan, N. W., Tate, R., Yusoff, Y. M., Clements, C. & Edrada-Ebel, R., 4 Jul 2019, In : Current Medicinal Chemistry. 26, p. 1-20 20 p.

Research output: Contribution to journalArticle

Avicennia
Metabolomics
Metabolites
Fungi
Cytotoxicity
2 Citations (Scopus)
9 Downloads (Pure)

New bioactive metabolites from the elicited marine sponge-derived bacterium Actinokineospora spheciospongiae sp. nov.

Tawfike, A., Attia, E. Z., Desoukey, S. Y., Hajjar, D., Makki, A. A., Schupp, P. J., Edrada-Ebel, R. & Abdelmohsen, U. R., 24 Jan 2019, In : AMB Express. 9, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
File
actinomycetes
Actinobacteria
metabolites
Porifera
activity (biology)
1 Citation (Scopus)

Tocolytic activity assessment of the methanol leaf extract of Justicia flava Vahl (Acanthaceae) on mouse myometrial contractility and preliminary mass spectrometric determination of secondary metabolites

Bafor, E. E., Ukpebor, F., Omoruyi, O., Ochoyama, E., Omogiade, G., Ekufu, J. & Edrada-Ebel, R., 28 Oct 2019, In : Journal of Ethnopharmacology. 243, 12 p., 112087.

Research output: Contribution to journalArticle

Justicia
Acanthaceae
Tocolytic Agents
Lignans
Methanol
chamomile
Matricaria chamomilla
data analysis
terpenoids
secondary metabolites
2018

A metabolomics approach to optimization of bioactive peptide production in marine bacterial co-cultures

Michelin, B. & Edrada-Ebel, R., 14 Nov 2018.

Research output: Contribution to conferencePoster

Metabolomics
Coculture Techniques
Rhodococcus
Lipase
Peptides
4 Citations (Scopus)
8 Downloads (Pure)

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri

Hamed, A. N. E., Schmitz, R., Bergermann, A., Totzke, F., Kubbutat, M., Müller, W. E. G., Youssef, D. T. A., Bishr, M. M., Kamel, M. S., Edrada-Ebel, R., Wätjen, W. & Proksch, P., 25 Apr 2018, In : Zeitschrift fur Naturforschung C. 73, 5-6, p. 199-210 12 p.

Research output: Contribution to journalArticle

Open Access
File
Indian Ocean
Pyrroles
Porifera
Alkaloids
Urea
1 Citation (Scopus)
12 Downloads (Pure)

Green tea inhibits uterine contractility in ex vivo (non-pregnant) mice models

Bafor, E. E., Eze, C., Omoruyi, O., Elvis-Offiah, B. U., Viegelmann, C. & Edrada-Ebel, R., 7 Jun 2018, In : Tropical Journal of Natural Product Research. 2, 6, p. 254-261 8 p.

Research output: Contribution to journalArticle

Open Access
File
Tea
Flavonoids
Cyclitols
Pteridines
Coumarins
6 Citations (Scopus)
9 Downloads (Pure)

Identification of GSK-3 as a potential therapeutic entry point for epilepsy

Aourz, N., Serruys, A-S. K., Chabwine, J. N., Balegamire, P. B., Afrikanova, T., Edrada-Ebel, R., Grey, A. I., Kamuhabwa, A. R., Walrave, L., Esguerra, C. V., van Leuven, F., de Witte, P. A. M., Smolders, I. & Crawford, A. D., 23 Oct 2018, In : ACS Chemical Neuroscience. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Glycogen Synthase Kinase 3
Anticonvulsants
Zebrafish
Epilepsy
Seizures
3 Citations (Scopus)
13 Downloads (Pure)

Metabolomic-guided isolation of bioactive natural products from Curvularia sp., an endophytic fungus of Terminalia laxiflora

Tawfike, A. F., Abbott, G., Young, L. & Edrada-Ebel, R., 28 Feb 2018, In : Planta Medica. 84, 3, p. 182-190 10 p.

Research output: Contribution to journalArticle

Open Access
File
Terminalia
Metabolomics
Metabolites
Biological Products
Fungi
2 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Pheophytins
Moraceae
Ficus
Metabolomics
Chlorophyll
9 Downloads (Pure)

Modulation of ex-vivo uterine contraction by the methanol leaf extract of Alchornea laxiflora Benth. (Euphorbiaceae) and preliminary spectrometric identification of associated secondary metabolites

Bafor, E. E., Nwogu, J. K., Elvis-Offiah, U. B., Amaechina, F., Ofeimun, J., Ayinde, B., Omoruyi, O., Viegelmann, C. & Edrada-Ebel, R., 6 Jun 2018, In : Journal of Medicinal Plants For Economic Development. 2, 1, 13 p., a33.

Research output: Contribution to journalArticle

Open Access
File
Euphorbiaceae
Uterine Contraction
Plant Extracts
Methanol
Oxytocin

SeaBioTech: from seabed to test-bed: harvesting the potential of marine biodiversity for industrial biotechnology

Edrada-Ebel, R., Ævarsson, A., Polymenakou, P., Hentschel, U., Carettoni, D., Day, J., Green, D., Hreggviðsson, G. Ó., Harvey, L. & McNeil, B., 28 May 2018, Grand Challenges in Marine Biotechnology. Rampelotto, P. H. & Trincone, A. (eds.). Cham: Springer, p. 451-504 54 p. (Grand Challenges in Biology and Biotechnology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Biodiversity
Biotechnology
Pipelines
Pharmaceutical Preparations
Hydrothermal Vents
2017
11 Citations (Scopus)
79 Downloads (Pure)

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

Thomson, S., Rice, C. A., Zhang, T., Edrada-Ebel, R., Henriquez, F. L. & Roberts, C. W., 15 Aug 2017, In : Scientific Reports. 7, 1, 9 p., 8247.

Research output: Contribution to journalArticle

Open Access
File
Acanthamoeba
Sterols
Azoles
Acanthamoeba castellanii
Ergosterol
4 Citations (Scopus)
83 Downloads (Pure)
Open Access
File
Ficus
ovarian neoplasms
Ovarian Neoplasms
Cells
Complex Mixtures
13 Downloads (Pure)

Dryopteris filix-mas (Dryopteridaceae) leaves inhibit mouse uterine activity

Bafor, E. E., Omokaro, W. O., Uwumarongie, O. H., Elvis-Offiah, U. B., Omoruyi, O., Edrada-Ebel, R. & Viegelmann, C. V., 25 Oct 2017, In : Journal of Medicinal Plants For Economic Development. 1, 1, 12 p., a25.

Research output: Contribution to journalArticle

Open Access
File
Dryopteridaceae
Dryopteris
Oxytocin
Uterine Contraction
Plant Extracts
9 Citations (Scopus)
304 Downloads (Pure)

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin, N. M., Baba, M. S., Zainal-Abidin, A. H., Latip, J., Mazlan, N. W. & Edrada-Ebel, R., 8 Feb 2017, In : Drug Design, Development and Therapy. 11, p. 351-363 13 p.

Research output: Contribution to journalArticle

Open Access
File
Antimalarials
Streptomyces
Dipterocarpaceae
Diketopiperazines
Body Weight
15 Downloads (Pure)
Open Access
File
Carica
Ficus
Neuroprotective Agents
Alzheimer Disease
Acrolein
5 Citations (Scopus)
263 Downloads (Pure)

Isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces SUK 25 with antimicrobial and cytotoxic activities

Alshaibani, M. M., Zin, N., Jalil, J., Sidik, N. M., Ahmad, S. J., Kamal, N. & Edrada-Ebel, R., 28 Jul 2017, In : Journal of Microbiology and Biotechnology. 27, 7, p. 1249-1256 8 p.

Research output: Contribution to journalArticle

Open Access
File
Diketopiperazines
Streptomyces
Enterococcus
Multiple Drug Resistance
phenylalanyl-valine
10 Citations (Scopus)
19 Downloads (Pure)

Isolation of petrocidin A, a new cytotoxic cyclic dipeptide from the marine sponge-derived bacterium Streptomyces sp. SBT348

Cheng, C., Othman, E. M., Stopper, H., Edrada-Ebel, R., Hentschel, U. & Abdelmohsen, U. R., 6 Dec 2017, In : Marine Drugs. 15, 12, 9 p.

Research output: Contribution to journalArticle

Open Access
File
Actinobacteria
Dipeptides
Streptomyces
Porifera
Mass Spectrometry
10 Citations (Scopus)
74 Downloads (Pure)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Aspergillus
Metabolites
Bioactivity
Complex Mixtures

P43 The isolation and purification of bioactive metabolites from Ficus carica and their neuroprotective effects in Alzheimer's disease

Khojah, H. & Edrada-Ebel, R., 1 Sep 2017, In : Biochemical Pharmacology. 139, Supplement C, p. 140 1 p.

Research output: Contribution to journalMeeting abstract

Carica
Ficus
Neuroprotective Agents
Metabolites
Purification
9 Citations (Scopus)
45 Downloads (Pure)

The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei

Omar, R., Igoli, J. O., Zhang, T., Gray, A. I., Ebiloma, G. U., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., de Koning, H. P. & Watson, D. G., 19 Apr 2017, In : Scientific Reports. 7, 1, 10 p., 01038.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei brucei
Liquid Chromatography
Mass Spectrometry
Nigeria
2016
1 Citation (Scopus)
142 Downloads (Pure)

Anti-infective activities of secondary metabolites from Vitex pinnata

Kamal, N., Clements, C., Gray, A. I. & Edrada-Ebel, R., 26 Jan 2016, In : Journal of Applied Pharmaceutical Science. 6, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

Open Access
File
flavone
Vitex
Mycobacterium marinum
Stigmasterol
Flavones
16 Citations (Scopus)
84 Downloads (Pure)

Chemical and antimicrobial profiling of propolis from different regions within Libya

Siheri, W., Zhang, T., Ebiloma, G. U., Biddau, M., Woods, N., Hussain, M. Y., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., Müller, S., Carter, K. C., Ferro, V. A., De Koning, H. P. & Watson, D. G., 19 May 2016, In : PLOS One. 11, 5, 16 p., e0155355.

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Mycobacterium marinum
Libya
Propolis
Leishmania donovani
30 Citations (Scopus)
117 Downloads (Pure)

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Omar, R. M. K., Igoli, J., Gray, A. I., Ebiloma, G. U., Clements, C., Fearnley, J., Edrada Ebel, R. A., Zhang, T., De Koning, H. P. & Watson, D. G., 31 Mar 2016, In : Phytochemical Analysis. 27, 2, p. 107–115 9 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei
Trypanosoma brucei brucei
propolis
Bioactivity
104 Citations (Scopus)
59 Downloads (Pure)

Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants

Sampaio, B. L., Edrada-Ebel, R. & Da Costa, F. B., 7 Jul 2016, In : Scientific Reports. 6, 29265.

Research output: Contribution to journalArticle

Open Access
File
Tithonia diversifolia
environmental models
metabolomics
metabolites
plant anatomy
2 Citations (Scopus)
1017 Downloads (Pure)

In vivo investigation of female reproductive functions and parameters in nonpregnant mice models and mass spectrometric analysis of the methanol leaf extract of Emilia Coccinea (Sims) G Dons

Elvis-Offiah, U. B., Bafor, E. E., Eze, G. I., Igbinumwen, O., Viegelmann, C. & Edrada-Ebel, R., 16 Dec 2016, In : Physiological Reports. 4, 23, e13047.

Research output: Contribution to journalArticle

Open Access
File
Methanol
Estrus
Nigeria
Estradiol
Toxic Plants
7 Citations (Scopus)
79 Downloads (Pure)

Isolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity

Alshaibani, M. M., Jalil, J., Sidik, N. M., Edrada-Ebel, R. & Zin, N. M., 31 May 2016, In : Drug Design, Development and Therapy. 10, p. 1817-1827 11 p.

Research output: Contribution to journalArticle

Open Access
File
Streptomyces
Chloramphenicol
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Diketopiperazines
8 Citations (Scopus)
44 Downloads (Pure)

Metabolomics-guided isolation of anti-trypanosomal metabolites from the endophytic fungus Lasiodiplodia theobromae

Kamal, N., Viegelmann, C. V., Clements, C. J. & Edrada-Ebel, R., 19 Oct 2016, In : Planta Medica.

Research output: Contribution to journalArticle

Open Access
File
Endophytes
Metabolomics
Liquid chromatography
Discriminant analysis
Metabolites
3 Citations (Scopus)
191 Downloads (Pure)

Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345

Cheng, C., Othman, E. M., Fekete, A., Krischke, M., Stopper, H., Edrada-Ebel, R. A., Mueller, M. J., Hentschel, U. & Abdelmohsen, U. R., 14 Sep 2016, In : Tetrahedron Letters. 57, 37, p. 4196-4199 4 p.

Research output: Contribution to journalArticle

Open Access
File
Phenazines
HL-60 Cells
Streptomyces
Porifera
Cytotoxicity
4 Citations (Scopus)
23 Downloads (Pure)
Open Access
File
Ritodrine
Metabolomics
Myometrium
Oxytocin
Adrenergic Agonists
17 Citations (Scopus)
76 Downloads (Pure)

Using molecular networking for microbial secondary metabolite bioprospecting

Purves, K., Macintyre, L., Brennan, D., Hreggviðsson, G. Ó., Kuttner, E., Ásgeirsdóttir, M. E., Young, L. C., Green, D. H., Edrada-Ebel, R. & Duncan, K., 8 Jan 2016, In : Metabolites. 6, 1, 18 p., 2.

Research output: Contribution to journalArticle

Open Access
File
Metabolites
Bacteria
Fermentation
Ions
Actinomyces
2015
31 Citations (Scopus)
65 Downloads (Pure)

A metabolomic approach to target compounds from the asteraceae family for dual COX and LOX inhibition

Chagas-Paula, D. A., Zhang, T., Da Costa, F. B. & Edrada-Ebel, R., 8 Jul 2015, In : Metabolites. 5, 3, p. 404-430 27 p.

Research output: Contribution to journalArticle

Open Access
File
Asteraceae
Metabolomics
Plant Extracts
Phytochemicals
Biomarkers
33 Citations (Scopus)
37 Downloads (Pure)

Biodiversity, anti-trypanosomal activity screening, and metabolomic profiling of actinomycetes isolated from Mediterranean sponges

Cheng, C., Macintyre, L., Abdelmohsen, U. R., Horn, H., Polymenakou, P. N., Edrada-Ebel, R. & Hentschel, U., 25 Sep 2015, In : PLOS One. 10, 9, 21 p., e0138528.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Actinobacteria
Biodiversity
metabolomics
Porifera
4 Citations (Scopus)
46 Downloads (Pure)

Draft genome sequences of three chemically rich actinomycetes isolated from Mediterranean sponges

Horn, H., Cheng, C., Edrada-Ebel, R., Hentschel, U. & Abdelmohsen, U. R., 1 Dec 2015, In : Marine Genomics. 24, p. 285-287 3 p.

Research output: Contribution to journalArticle

Open Access
File
Actinobacteria
Porifera
sponge
genome
Genome
85 Citations (Scopus)
129 Downloads (Pure)

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

Zheng, L., Cardaci, S., Jerby, L., Mackenzie, E. D., Sciacovelli, M., Johnson, T. I., Gaude, E., King, A., Leach, J. D. G., Edrada-Ebel, R., Hedley, A., Morrice, N. A., Kalna, G., Blyth, K., Ruppin, E., Frezza, C. & Gottlieb, E., 23 Jan 2015, In : Nature Communications. 6, 12 p., 6001.

Research output: Contribution to journalArticle

Open Access
File
Fumarate Hydratase
Fumarates
glutathione
metabolism
Metabolism
10 Citations (Scopus)
80 Downloads (Pure)

In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10

Baba, M. S., Zin, N. M., Hassan, Z. A. A., Latip, J., Pethick, F., Hunter, I. S., Edrada-Ebel, R. & Herron, P. R., 5 Dec 2015, In : Journal of Microbiology. 53, 12, p. 847-855 9 p.

Research output: Contribution to journalArticle

Open Access
File
Actinobacteria
Antimalarials
Streptomyces
Complex Mixtures
Plasmodium berghei
286 Downloads (Pure)

Metabolomics and dereplication strategies in the discovery of natural product derived drugs

Tawfike, AF., Tawfik, N. & Edrada-Ebel, R., 23 Aug 2015, In : Planta Medica. 81, 16, SL3A_02.

Research output: Contribution to journalConference Contribution

File
Metabolomics
Metabolites
Biological Products
Pharmaceutical Preparations
Bioactivity
19 Downloads (Pure)

Metabolomics and dereplication study of the British bluebell

Tawfike, A., Raheem, D., Thoss, V. & Edrada-Ebel, R., 24 Jun 2015, p. 301. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Metabolomics
Drug Discovery
Biological Products
29 Citations (Scopus)
84 Downloads (Pure)

Metabolomics of the bio-degradation process of aflatoxin B1 by actinomycetes at an initial pH of 6.0

Eshelli, M., Harvey, L., Edrada-Ebel, R. & McNeil, B., 4 Feb 2015, In : Toxins. 7, 2, p. 439-456 18 p.

Research output: Contribution to journalArticle

Open Access
File
Aflatoxin B1
Metabolomics
Actinobacteria
Biodegradation
Degradation
2 Citations (Scopus)
106 Downloads (Pure)

The 9th European conference on marine natural products

Edrada-Ebel, R. & Jaspars, M., 3 Dec 2015, In : Marine Drugs. 13, 12, p. 7150-7249 100 p.

Research output: Contribution to journalArticle

Open Access
File
Ischium
Paris
Biological Products
844 Citations (Scopus)
461 Downloads (Pure)

The re-emergence of natural products for drug discovery in the genomics era

Harvey, A., Edrada-Ebel, R. & Quinn, R. J., 23 Jan 2015, In : Nature Reviews Drug Discovery . 14, p. 111–129 19 p.

Research output: Contribution to journalLiterature review

Open Access
File
Drug Discovery
Genomics
Biological Products
Metabolomics
Proteins
22 Citations (Scopus)
261 Downloads (Pure)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Lactoferrin
Intravenous Administration
Tumors
Dendrimers
2014
33 Citations (Scopus)

Chromatographic analysis with different detectors in the chemical characterisation and dereplication of African propolis

Zhang, T., Omar, R., Siheri, W., Al Mutairi, S., Clements, C., Fearnley, J., Edrada-Ebel, R. & Watson, D., 1 Mar 2014, In : Talanta. 120, p. 181-190 10 p.

Research output: Contribution to journalArticle

Chromatographic analysis
Propolis
Chromatography
Detectors
Liquid chromatography