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  • 2020
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Author

  • Nigel Pyne

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. J. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
Open Access
File
12 Citations (Scopus)
22 Downloads (Pure)

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Alsanafi, M., Kelly, S. L., McNaughton, M., Merrill Jr., A. H., Pyne, N. J. & Pyne, S., 30 Apr 2020, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1865, 4, 10 p., 158631.

Research output: Contribution to journalSpecial issue

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

Evangelisti, C., Evangelisti, C., Buontempo, F., Lonetti, A., Orsini, E., Chiarini, F., Barata, J. T., Pyne, S., Pyne, N. J. & Martelli, A. M., 1 Nov 2016, In : Leukemia. 30, p. 2142–2151 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
15 Citations (Scopus)
207 Downloads (Pure)

Sphingosine kinases as druggable targets

Pyne, S., Adams, D. R. & Pyne, N. J., 25 Apr 2020, Lipid Signaling in Human Diseases: Handbook of Experimental Pharmacology. Gomez-Cambronero, J. & Frohman, M. A. (eds.). Cham, Switzerland, Vol. 259. p. 49-76 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Sphingosine kinases: emerging structure function insights

Adams, D. R., Pyne, S. & Pyne, N. J., 1 May 2016, In : Trends in Biochemical Sciences . 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
46 Downloads (Pure)

Sphingosine kinase 2 in autoimmune/inflammatory disease and development of sphingosine kinase 2 inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., 31 Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
11 Citations (Scopus)
26 Downloads (Pure)

Sphingosine kinase 2 and multiple myeloma

Pyne, N. J. & Pyne, S., 25 Apr 2017, In : Oncotarget. 8, 24, p. 43596-43597 2 p., 17420.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
23 Downloads (Pure)

Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1

Hii, L-W., Chung, F. F-L., Mai, C. W., Yee, Z. Y., Chan, H. H., Raja, V. J., Dephoure, N. E., Pyne, N. J., Pyne, S. & Leong, C-O., 4 Apr 2020, In : Cells. 9, 4, 25 p., 886.

Research output: Contribution to journalArticle

Open Access
File

Sphingosine kinase1: a potential therapeutic target in pulmonary arterial hypertension?

Pyne, N. J. & Pyne, S., 30 Sep 2017, In : Trends in Molecular Medicine. 23, 9, p. 786-798 13 p.

Research output: Contribution to journalComment/debate

Open Access
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12 Citations (Scopus)
9 Downloads (Pure)

Sphingosine 1-phosphate turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Pyne, N. J. & Pyne, S., 16 Sep 2019, In : IUPHAR/BPS Guide to Pharmacology CITE. 2019, 4, 3 p.

Research output: Contribution to journalShort survey

Open Access
File
1 Downloads (Pure)

Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, N. J. & Pyne, S., 23 Feb 2017, In : Molecules. 22, 3, p. 1-18 18 p., 344.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
171 Downloads (Pure)

Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., 1 Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalLiterature review

Open Access
File
75 Citations (Scopus)
157 Downloads (Pure)

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., 12 May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
23 Citations (Scopus)
94 Downloads (Pure)

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, Houslay, M. D. & Henderson, D. J. P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3

Alganga, H., Almabrouk, T. A. M., Katwan, O. J., Daly, C. J., Pyne, S., Pyne, N. J. & Kennedy, S., 31 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H-R., Ubhi, S. K. & Pyne, S., 1 Jan 2016, In : Advances in Biological Regulation. 60, p. 151-159 9 p.

Research output: Contribution to journalArticle

Open Access
File
82 Citations (Scopus)
88 Downloads (Pure)

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
11 Downloads (Pure)
Open Access
File
40 Citations (Scopus)
245 Downloads (Pure)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
10 Downloads (Pure)

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N. J., 31 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 10 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
64 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
20 Downloads (Pure)

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis

Boomkamp, S. D., Byun, H-S., Ubhi, S., Jiang, H-R., Pyne, S., Bittman, R. & Pyne, N. J., 1 Jan 2016, In : Chemistry and Physics of Lipids. 194, p. 2-11 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
25 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
8 Downloads (Pure)

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang, Z., Pyne, S. & Pyne, N. J., 30 Apr 2019, In : Progress in Lipid Research. 74, p. 145-159 15 p.

Research output: Contribution to journalReview article

Open Access
File
2 Citations (Scopus)
4 Downloads (Pure)

Cellular Signalling – Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz

Shukla, A. K. & Pyne, N. J., 1 Jan 2018, In : Cellular Signalling. 41, p. 1 1 p.

Research output: Contribution to journalEditorial

Open Access
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7 Downloads (Pure)
Open Access
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61 Downloads (Pure)