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  • Nigel Pyne

Translational aspects of sphingosine 1-phosphate biology

Pyne, S. & Pyne, N. J., 2011, In : Trends in Molecular Medicine. 17, p. 463-472

Research output: Contribution to journalLiterature review

53 Citations (Scopus)

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. J. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
Open Access
File
12 Citations (Scopus)
22 Downloads (Pure)

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells

Watson, D. G., Tonelli, F., Al Osaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N. J. & Pyne, S., Apr 2013, In : Cellular Signalling. 25, 4, p. 1011-1017 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells

Tonelli, F., Alossaimi, M., Natarajan, V., Gorshkova, I., Berdyshev, E., Bittman, R., Watson, D. G., Pyne, S. & Pyne, N. J., 2013, In : Biomolecules. 3, 2, p. 316-333 18 p.

Research output: Contribution to journalArticle

Open Access
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63 Downloads (Pure)

The role of sphingosine 1-phosphate in inflammation and cancer

Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S., Jan 2014, In : Advances in Biological Regulation. 54, p. 121-129 9 p.

Research output: Contribution to journalLiterature review

Open Access
File
39 Citations (Scopus)
174 Downloads (Pure)

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Alsanafi, M., Kelly, S. L., McNaughton, M., Merrill Jr., A. H., Pyne, N. J. & Pyne, S., 30 Apr 2020, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1865, 4, 10 p., 158631.

Research output: Contribution to journalSpecial issue

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

Evangelisti, C., Evangelisti, C., Buontempo, F., Lonetti, A., Orsini, E., Chiarini, F., Barata, J. T., Pyne, S., Pyne, N. J. & Martelli, A. M., 1 Nov 2016, In : Leukemia. 30, p. 2142–2151 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
15 Citations (Scopus)
207 Downloads (Pure)

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism

Gibriel, A., Tate, R., Yu, Y., Rawson-Lax, E., Hammer, HM., Tettey, J. N. A., Pyne, N. & Converse, C., 15 Feb 2013, In : Gene. 515, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The life and work of Dr Robert Bittman (1942-2014)

Pyne, N. J. & Kolesnick, R. N., Jun 2015, In : Biological Chemistry. 396, 6-7, p. 827-830 4 p.

Research output: Contribution to journalComment/debate

Open Access
File
85 Downloads (Pure)

The Concise Guide to PHARMACOLOGY 2013/14: overview

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., McGrath, J. C., Catterall, W. A., Spedding, M., Peters, J. A., Harmar, A. J., Abul-Hasn, N., Anderson, C. M., Anderson, C. M. H., Araiksinen, M. S., Arita, M., Arthofer, E., Barker, E. L., Barratt, C., Barnes, N. M., Bathgate, R. & 31 others, Beart, P. M., Belelli, D., Bennett, A. J., Birdsall, N. J. M., Boison, D., Bonner, T. I., Brailsford, L., Bröer, S., Brown, P., Calo, G., Carter, W. G., Catterall, W. A., Chan, S. L. F., Chao, M. V., Chiang, N., Christopoulos, A., Chun, J. J., Cidlowski, J., Clapham, D. E., Cockcroft, S., Connor, M. A., Cox, H. M., Cuthbert, A., Dautzenberg, F. M., Davenport, A. P., Dawson, P. A., Jones, R. L., Kennedy, C., Pyne, N. J., Pyne, S. & CGTP Collaborators, Dec 2013, In : British Journal of Pharmacology. 170, 8, p. 1449-58 10 p.

Research output: Contribution to journalSpecial issue

133 Citations (Scopus)

Targeting sphingosine kinase 1 in cancer

Pyne, N. J., Tonelli, F., Lim, K. G., Long, J., Edwards, J. & Pyne, S., Jan 2012, In : Advances in Biological Regulation. 52, 1, p. 31–38 8 p.

Research output: Contribution to journalLiterature review

22 Citations (Scopus)

Synthesis of selective inhibitors of sphingosine kinase 1

Baek, D. J., MacRitchie, N., Pyne, N., Pyne, S. & Bittman, R., 2013, In : Chemical Communications (London). 4 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Liu, Z., MacRitchie, N., Pyne, S., Pyne, N. J. & Bittman, R., 1 May 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2503-2510 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors

Baek, D. J., MacRitchie, N., Anthony, N. G., Mackay, S. P., Pyne, S., Pyne, N. J. & Bittman, R., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9310-9327 18 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
164 Downloads (Pure)

Sphingosine kinases as druggable targets

Pyne, S., Adams, D. R. & Pyne, N. J., 25 Apr 2020, Lipid Signaling in Human Diseases: Handbook of Experimental Pharmacology. Gomez-Cambronero, J. & Frohman, M. A. (eds.). Cham, Switzerland, Vol. 259. p. 49-76 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Sphingosine kinases: emerging structure function insights

Adams, D. R., Pyne, S. & Pyne, N. J., 1 May 2016, In : Trends in Biochemical Sciences . 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
46 Downloads (Pure)

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

Pyne, S., Bittman, R. & Pyne, N., 2011, In : Cancer Research. 71, 21, p. 6576-6582 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
Open Access
File
18 Citations (Scopus)
88 Downloads (Pure)

Sphingosine kinase 2 in autoimmune/inflammatory disease and development of sphingosine kinase 2 inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., 31 Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
11 Citations (Scopus)
26 Downloads (Pure)

Sphingosine kinase 2 and multiple myeloma

Pyne, N. J. & Pyne, S., 25 Apr 2017, In : Oncotarget. 8, 24, p. 43596-43597 2 p., 17420.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
23 Downloads (Pure)

Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1

Hii, L-W., Chung, F. F-L., Mai, C. W., Yee, Z. Y., Chan, H. H., Raja, V. J., Dephoure, N. E., Pyne, N. J., Pyne, S. & Leong, C-O., 4 Apr 2020, In : Cells. 9, 4, 25 p., 886.

Research output: Contribution to journalArticle

Open Access
File

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

Pyne, N. J. & Pyne, S., 26 Jun 2014, In : Oncogene. 33, 26, p. 3361-3363 3 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
79 Downloads (Pure)

Sphingosine kinase1: a potential therapeutic target in pulmonary arterial hypertension?

Pyne, N. J. & Pyne, S., 30 Sep 2017, In : Trends in Molecular Medicine. 23, 9, p. 786-798 13 p.

Research output: Contribution to journalComment/debate

Open Access
File
12 Citations (Scopus)
9 Downloads (Pure)

Sphingosine 1-phosphate turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Pyne, N. J. & Pyne, S., 16 Sep 2019, In : IUPHAR/BPS Guide to Pharmacology CITE. 2019, 4, 3 p.

Research output: Contribution to journalShort survey

Open Access
File
1 Downloads (Pure)

Sphingosine 1 phosphate signalling in cancer

Pyne, N. J., Tonelli, F., Lim, K. G., Long, J. S., Edwards, J. & Pyne, S., 2012, In : Biochemical Society Transactions. 40, 1, p. 94-100 7 p.

Research output: Contribution to journalLiterature review

88 Citations (Scopus)
Open Access
File
6 Downloads (Pure)

Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, N. J. & Pyne, S., 23 Feb 2017, In : Molecules. 22, 3, p. 1-18 18 p., 344.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
171 Downloads (Pure)

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Pyne, S. & Pyne, N., 14 Jan 2013, In : Cancer Cell. 23, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., 1 Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalLiterature review

Open Access
File
75 Citations (Scopus)
157 Downloads (Pure)

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., 12 May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
23 Citations (Scopus)
94 Downloads (Pure)

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, Houslay, M. D. & Henderson, D. J. P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3

Alganga, H., Almabrouk, T. A. M., Katwan, O. J., Daly, C. J., Pyne, S., Pyne, N. J. & Kennedy, S., 31 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access
Open Access
File
25 Citations (Scopus)
7 Downloads (Pure)

Selective inhibitors and allosteric activators of sphingosine kinase

Bittman, R., Pyne, N., Pyne, S., Baek, D. J., Liu, Z. & Byun, H-S., 7 Aug 2014, IPC No. C07D401/04, Patent No. PCT/GB2014/050264, Priority date 31 Jan 2013

Research output: Patent

138 Downloads (Pure)

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H-R., Ubhi, S. K. & Pyne, S., 1 Jan 2016, In : Advances in Biological Regulation. 60, p. 151-159 9 p.

Research output: Contribution to journalArticle

Open Access
File
82 Citations (Scopus)
88 Downloads (Pure)

Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis

Pyne, N., Dubois, G. & Pyne, S., Jan 2013, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1831, 1, p. 228-238 10 p.

Research output: Contribution to journalSpecial issue

35 Citations (Scopus)
37 Citations (Scopus)

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

Lim, K. G., Gray, A. I., Anthony, N. G., MacKay, S. P., Pyne, S. & Pyne, N. J., 25 Oct 2014, In : Archives of Toxicology. 88, 12, p. 2213-2232 20 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
513 Downloads (Pure)

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
11 Downloads (Pure)

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Rutherford, C., Childs, S., Ohotski, J., McGlynn, L., Riddick, M., MacFarlane, S., Tasker, D., Pyne, S., Pyne, N. J., Edwards, J. & Palmer, T. M., 21 Nov 2013, In : Cell Death and Disease. 4, 15 p., e927.

Research output: Contribution to journalArticle

45 Citations (Scopus)
67 Citations (Scopus)
Open Access
File
40 Citations (Scopus)
245 Downloads (Pure)
Open Access
File
43 Citations (Scopus)
92 Downloads (Pure)

New perspectives on the role of sphingosine 1-phosphate in cancer

Pyne, S. & Pyne, N., 31 Mar 2013, Sphingolipids in Disease. Gulbins, E. & Petrache, I. (eds.). Vienna: Springer-Verlag, p. 55-71 17 p. (Handbook of experimental pharmacology ; no. 216).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
10 Downloads (Pure)

Lysophospholipid receptor signalling platforms: the receptor tyrosine kinase-G-protein coupled receptor signaling complex

Pyne, N. & Pyne, S., Nov 2012, Lysophospholipid Receptors: Signaling and Biochemistry. Chun, J. (ed.). Chichester: John Wiley & Sons Inc., p. 85-102 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase

Berdyshev, E. V., Gorshkova, I., Usatyuk, P., Kalari, S., Zhao, Y., Pyne, N. J., Pyne, S., Sabbadini, R. A., Garcia, J. G. N. & Natarajan, V., 31 Jan 2011, In : PLoS One. 6, 1, p. e16571

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
61 Downloads (Pure)

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b

Lim, K. G., Tonelli, F. R., Berdyshev, E., Gorshkova, I., Leclercq, T., Pitson, S. M., Bittman, R., Pyne, S. & Pyne, N., Sep 2012, In : International Journal of Biochemistry and Cell Biology. 44, 9, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)