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  • Ruangelie Edrada-Ebel

Using molecular networking for microbial secondary metabolite bioprospecting

Purves, K., Macintyre, L., Brennan, D., Hreggviðsson, G. Ó., Kuttner, E., Ásgeirsdóttir, M. E., Young, L. C., Green, D. H., Edrada-Ebel, R. & Duncan, K., 8 Jan 2016, In : Metabolites. 6, 1, 18 p., 2.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
79 Downloads (Pure)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
264 Downloads (Pure)
Open Access
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5 Citations (Scopus)
23 Downloads (Pure)

Towards better understanding of an industrial cell factory: investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris

Fazenda, M. L., Dias, J. M. L., Harvey, L. M., Nordon, A. & Edrada-Ebel, R., 21 May 2013, In : Microbial Cell Factories. 12, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
73 Downloads (Pure)

Tocolytic activity assessment of the methanol leaf extract of Justicia flava Vahl (Acanthaceae) on mouse myometrial contractility and preliminary mass spectrometric determination of secondary metabolites

Bafor, E. E., Ukpebor, F., Omoruyi, O., Ochoyama, E., Omogiade, G., Ekufu, J. & Edrada-Ebel, R., 28 Oct 2019, In : Journal of Ethnopharmacology. 243, 12 p., 112087.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The re-emergence of natural products for drug discovery in the genomics era

Harvey, A., Edrada-Ebel, R. & Quinn, R. J., 23 Jan 2015, In : Nature Reviews Drug Discovery . 14, p. 111–129 19 p.

Research output: Contribution to journalLiterature review

Open Access
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906 Citations (Scopus)
514 Downloads (Pure)

The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents

Bafor, E. E., Lim, C. V., Rowan, E. G. & Edrada-Ebel, R., 13 Feb 2013, In : Journal of Ethnopharmacology. 145, 3, p. 803–812 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The isolation of antiprotozoal compounds from Libyan propolis

Siheri, W., Igoli, J. O., Gray, A. I., Nasciemento, T. G., Zhang, T., Fearnley, J., Clements, C. J., Carter, K. C., Carruthers, J., Edrada-Ebel, R. & Watson, D. G., Dec 2014, In : Phytotherapy Research. 28, 12, p. 1756–1760 5 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
174 Downloads (Pure)

The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei

Omar, R., Igoli, J. O., Zhang, T., Gray, A. I., Ebiloma, G. U., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., de Koning, H. P. & Watson, D. G., 19 Apr 2017, In : Scientific Reports. 7, 1, 10 p., 01038.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
45 Downloads (Pure)

The 9th European conference on marine natural products

Edrada-Ebel, R. & Jaspars, M., 3 Dec 2015, In : Marine Drugs. 13, 12, p. 7150-7249 100 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
106 Downloads (Pure)

Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae)

Bafor, E., Lim, C. V., Rowan, E. & Edrada-Ebel, R., Jul 2012, p. PG10. 1 p.

Research output: Contribution to conferencePoster

Streptomyces kebangsaanensis sp. nov., an endophytic actinomycete isolated from an ethnomedicinal plant, which produces phenazine-1-carboxylic acid

Sarmin, N. I. M., Tan, G-Y. A., Franco, C. M. M., Edrada-Ebel, R., Latip, J. & Zin, N., 1 Oct 2013, In : Journal of Systematic and Evolutionary Microbiology. 63, 10, p. 3733-3738 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345

Cheng, C., Othman, E. M., Fekete, A., Krischke, M., Stopper, H., Edrada-Ebel, R. A., Mueller, M. J., Hentschel, U. & Abdelmohsen, U. R., 14 Sep 2016, In : Tetrahedron Letters. 57, 37, p. 4196-4199 4 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
237 Downloads (Pure)

SeaBioTech: from seabed to test-bed: harvesting the potential of marine biodiversity for industrial biotechnology

Edrada-Ebel, R., Ævarsson, A., Polymenakou, P., Hentschel, U., Carettoni, D., Day, J., Green, D., Hreggviðsson, G. Ó., Harvey, L. & McNeil, B., 28 May 2018, Grand Challenges in Marine Biotechnology. Rampelotto, P. H. & Trincone, A. (eds.). Cham: Springer, p. 451-504 54 p. (Grand Challenges in Biology and Biotechnology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
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1 Downloads (Pure)

SeaBioTech: from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology

MacIntyre, L., Zhang, T., Viegelmann, C. V., Cheng, C., Perrocco, D., Dowdells, C., Hentschel-Humeida, U., Abdelmohsen, U. R., Martinez, I. J., Moss, O. & Edrada-Ebel, R., Sep 2013.

Research output: Contribution to conferencePoster

Screening for novel anti-trypanosomal drugs through metabolomic tools

Edrada-Ebel, R., 27 Apr 2011.

Research output: Contribution to conferenceSpeech

Perfusion culture enhanced human endometrial stromal cell growth in alginate-multivalent integrin α5β1 ligand scaffolds

Li, Z., Kreiner, M., Edrada-Ebel, R., Cui, Z., van der Walle, C. F. & Mardon, H. J., Nov 2011, In : Journal of Biomedical Materials Research Part A. 99A, 2, p. 211-220 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

P43 The isolation and purification of bioactive metabolites from Ficus carica and their neuroprotective effects in Alzheimer's disease

Khojah, H. & Edrada-Ebel, R., 1 Sep 2017, In : Biochemical Pharmacology. 139, Supplement C, p. 140 1 p.

Research output: Contribution to journalMeeting abstract

Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus

Liu, H. B., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Muller, W. E. G., Wray, V., Lin, W. H. & Proksch, P., Apr 2011, In : Helvetica Chimica Acta. 94, 4, p. 623-631 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Nuclear magnetic resonance spectroscopy

Edrada-Ebel, R., Jul 2012, Pharmaceutical Analysis: A Textbook for Pharmacy Students and Pharmaceutical Chemists. Watson, D. (ed.). 3 ed. Edinburgh: Elsevier Science

Research output: Chapter in Book/Report/Conference proceedingChapter

NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum

Aly, A. H., Debbab, A., Clements, C., Edrada-Ebel, R., Orlikova, B., Diederich, M., Wray, V., Lin, W. & Proksch, P., 2011, In : Bioorganic and Medicinal Chemistry . 19, 1, p. 414-21 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

New rocaglamide derivatives from Vietnamese Aglaia species

Duong, N. T., Edrada-Ebel, R., Ebel, R., Lin, W., Duong, A. T., Dang, X. Q., Nguyen, N. H. & Proksch, P., 1 Jun 2014, In : Natural Product Communications. 9, 6, p. 833-834 2 p.

Research output: Contribution to journalArticle

New bioactive metabolites from the elicited marine sponge-derived bacterium Actinokineospora spheciospongiae sp. nov.

Tawfike, A., Attia, E. Z., Desoukey, S. Y., Hajjar, D., Makki, A. A., Schupp, P. J., Edrada-Ebel, R. & Abdelmohsen, U. R., 24 Jan 2019, In : AMB Express. 9, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
15 Downloads (Pure)

New anthracene derivatives – structure elucidation and antimicrobial activity

Debbab, A., Aly, A. H., Edrada-Ebel, R., Wray, V., Pretsch, A., Pescitelli, G., Kurtan, T. & Proksch, P., 2012, In : European Journal of Organic Chemistry. 2012, p. 1351-1359 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Natural products isolation in modern drug discovery programs

Gray, A. I., Igoli, J. O. & Edrada-Ebel, R., 2012, In : Methods in Molecular Biology. 864, p. 515-34 20 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Morphological, genotypic and metabolomic signatures confirm interfamilial hybridization between the ubiquitous kelps Macrocystis (Arthrothamnaceae) and Lessonia (Lessoniaceae)

Murúa, P., Edrada-Ebel, R. A., Muñoz, L., Soldatou, S., Legrave, N., Müller, D. G., Patiño, D. J., can West, P., Küpper, F. C., Westermeier, R., Ebel, R. & Peters, A. F., 19 May 2020, In : Scientific Reports. 10, 1, 15 p., 8279.

Research output: Contribution to journalArticle

Open Access
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Modulation of ex-vivo uterine contraction by the methanol leaf extract of Alchornea laxiflora Benth. (Euphorbiaceae) and preliminary spectrometric identification of associated secondary metabolites

Bafor, E. E., Nwogu, J. K., Elvis-Offiah, U. B., Amaechina, F., Ofeimun, J., Ayinde, B., Omoruyi, O., Viegelmann, C. & Edrada-Ebel, R., 6 Jun 2018, In : Journal of Medicinal Plants For Economic Development. 2, 1, 13 p., a33.

Research output: Contribution to journalArticle

Open Access
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9 Downloads (Pure)

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

Hulme, H., Meikle, L. M., Strittmatter, N., van der Hooft, J. J. J., Swales, J., Bragg, R. A., Villar, V. H., Ormsby, M. J., Barnes, S., Brown, S. L., Dexter, A., Kamat, M. T., Komen, J. C., Walker, D., Milling, S., Osterweil, E. K., MacDonald, A. S., Schofield, C. J., Tardito, S., Bunch, J. & 6 others, Douce, G., Edgar, J. M., Edrada-Ebel, R., Goodwin, R. J. A., Burchmore, R. & Wall, D. M., 11 Mar 2020, In : Science Advances. 6, 11, 11 p., eaax6328.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
2 Downloads (Pure)

Metabolomic tools used in marine natural product drug discovery

Stuart, K. A., Welsh, K., Walker, M. C. & Edrada-Ebel, R., 2 Apr 2020, In : Expert Opinion on Drug Discovery. 15, 4, p. 499-522 24 p.

Research output: Contribution to journalReview article

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
92 Downloads (Pure)

Metabolomic tools for secondary metabolite discovery from marine microbial symbionts

Macintyre, L., Zhang, T., Viegelmann, C., Martinez, I. J., Cheng, C., Dowdells, C., Abdelmohsen, U. R., Gernert, C., Hentschel, U. & Edrada-Ebel, R. A., 5 Jun 2014, In : Marine Drugs. 12, 6, p. 3416-3448 33 p.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
75 Downloads (Pure)

Metabolomic strategies in dereplication for targeted cultivation and isolation of new bioactive secondary metabolites from fungal endophytes and marine microbial symbionts

Cheng, C., Abdelmohsen, U. R., Grkovic, T., Quinn, R., Hentschel, U. & Edrada-Ebel, R., Aug 2013, In : Planta Medica. 79, 13, 1 p., SL29.

Research output: Contribution to journalConference Contribution

Metabolomics studies of endophytic metabolites from Malaysian mangrove plant in the search for new potential antibiotics

Noor Wini Binti Mazlan, N., Tate, R., Clements, C. & Edrada-Ebel, R., Aug 2013, In : Planta Medica. 79, 13, 1 p., PA22.

Research output: Contribution to journalConference Contribution

Metabolomics of the bio-degradation process of aflatoxin B1 by actinomycetes at an initial pH of 6.0

Eshelli, M., Harvey, L., Edrada-Ebel, R. & McNeil, B., 4 Feb 2015, In : Toxins. 7, 2, p. 439-456 18 p.

Research output: Contribution to journalArticle

Open Access
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36 Citations (Scopus)
86 Downloads (Pure)

Metabolomics of plant endophytes and marine microbial symbionts

Edrada-Ebel, R., 30 May 2011.

Research output: Contribution to conferenceSpeech

Metabolomics-guided isolation of anti-trypanosomal metabolites from the endophytic fungus Lasiodiplodia theobromae

Kamal, N., Viegelmann, C. V., Clements, C. J. & Edrada-Ebel, R., 19 Oct 2016, In : Planta Medica.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
46 Downloads (Pure)

Metabolomics-guided isolation of anti-trypanosomal compounds from endophytic fungi of the mangrove plant Avicennia lanata

Mazlan, N. W., Tate, R., Yusoff, Y. M., Clements, C. & Edrada-Ebel, R., 1 Jan 2020, In : Current Medicinal Chemistry. 27, 11, p. 1815-1835 21 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
Open Access
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2 Citations (Scopus)
11 Downloads (Pure)

Metabolomics as a tool in the identification and production of new antibiotics from sponges and endosymbiotic bacteria

Viegelmann, C. V., Hoe Leong, C., Clements, C., Abdelmohsen, U. R., Hentschel, U., Margassery, L. M., Kennedy, J., Perrocco, D., Dobson, A. D. W. & Edrada-Ebel, R., Feb 2013.

Research output: Contribution to conferencePoster

Metabolomics as a tool in dereplication studies of microbial symbionts

Viegelmann, C. V., Zhang, T. & Edrada-Ebel, R., 21 Mar 2011.

Research output: Contribution to conferencePoster

Metabolomics and dereplication study of the British bluebell

Tawfike, A., Raheem, D., Thoss, V. & Edrada-Ebel, R., 24 Jun 2015, p. 301. 1 p.

Research output: Contribution to conferencePoster

Open Access
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20 Downloads (Pure)

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Tawfike, A. F., Edrada-Ebel, R., Tate, R., Diederich, M., Schumacher, M., Sawadogo, R., Clements, C. & Young, L., 23 Jun 2014, p. 116. 1 p.

Research output: Contribution to conferencePoster

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in search for new potential anti-cancer drugs

Tawfike, A. F. S., Romli, M., Tate, R., Diederich, M., Schumacher, M. & Edrada-Ebel, R., Sep 2012.

Research output: Contribution to conferencePoster

Metabolomics and dereplication strategies in the discovery of natural product derived drugs

Tawfike, AF., Tawfik, N. & Edrada-Ebel, R., 23 Aug 2015, In : Planta Medica. 81, 16, SL3A_02.

Research output: Contribution to journalConference Contribution

File
286 Downloads (Pure)

Metabolomics and dereplication strategies in natural products

Tawfike, A. F., Viegelmann, C. & Edrada-Ebel, R., 19 Sep 2013, Metabolomics Tools for Natural Product Discovery: Methods and Protocols. Springer, Vol. 1055. p. 227-244 18 p. (Methods in Molecular Biology; vol. 1055).

Research output: Chapter in Book/Report/Conference proceedingChapter

47 Citations (Scopus)

Metabolomic profiling and genomic study of a marine sponge-associated streptomyces sp

Viegelmann, C. V., Margassery, L. M., Kennedy, J., Zhang, T., O’Brien, C., O’Gara, F., Morrissey, J. P., Dobson, A. D. W. & Edrada-Ebel, R., 2 Jun 2014, In : Marine Drugs. 12, 6, p. 3323-3351 29 p.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
66 Downloads (Pure)

Metabolomic-guided isolation of bioactive natural products from Curvularia sp., an endophytic fungus of Terminalia laxiflora

Tawfike, A. F., Abbott, G., Young, L. & Edrada-Ebel, R., 28 Feb 2018, In : Planta Medica. 84, 3, p. 182-190 10 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
14 Downloads (Pure)

Isolation of petrocidin A, a new cytotoxic cyclic dipeptide from the marine sponge-derived bacterium Streptomyces sp. SBT348

Cheng, C., Othman, E. M., Stopper, H., Edrada-Ebel, R., Hentschel, U. & Abdelmohsen, U. R., 6 Dec 2017, In : Marine Drugs. 15, 12, 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
19 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
6 Downloads (Pure)