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Author

  • Alan Harvey

Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum

Challal, S., Buenafe, O. E. M., Queiroz, E. F., Maljevic, S., Marcourt, L., Bock, M., Kloeti, W., Dayrit, F. M., Harvey, A. L., Lerche, H., Esguerra, C. V., de Witte, P. A. M., Wolfender, J-L. & Crawford, A. D., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 993-1004 12 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
151 Downloads (Pure)

Toxins and drug discovery

Harvey, A. L., 15 Dec 2014, In : Toxicon. 92, p. 193-200 8 p.

Research output: Contribution to journalArticle

Open Access
File
95 Citations (Scopus)
149 Downloads (Pure)

Toxicon: Letter from the outgoing editor

Harvey, A., 15 Jun 2017, In : Toxicon. 132, p. 18 1 p.

Research output: Contribution to journalLetter

The re-emergence of natural products for drug discovery in the genomics era

Harvey, A., Edrada-Ebel, R. & Quinn, R. J., 23 Jan 2015, In : Nature Reviews Drug Discovery . 14, p. 111–129 19 p.

Research output: Contribution to journalLiterature review

Open Access
File
906 Citations (Scopus)
514 Downloads (Pure)
5 Citations (Scopus)

Synthesis of quaternary ammonium salts of 16E-[4-(2-alkylaminoethoxy)-3-methoxybenzylidene]androstene derivatives as skeletal muscle relaxants

Bansal, R., Guleria, S., Young, L. C. & Harvey, A. L., Feb 2011, In : Steroids. 76, 3, p. 254-260 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of a new series of 4-Aryl-1,4-dihydropyridines with calcium channel blocking and vasodilatory activity

Bansal, R., Jain, P., Calle, C., Carron, R., Pemberton, K. & Harvey, A. L., 1 Jun 2012, In : Medicinal Chemistry Research. 21, 6, p. 908-921 14 p.

Research output: Contribution to journalArticle

Synthesis of a new series of 1H-imidazol-1-yl substituted 8-phenylxanthines as adenosine receptor ligands

Bansal, R., Kumar, G., Gandhi, D., Young, L. C. & Harvey, A. L., 2011, In : Chemistry and Biodiversity. 8, 7, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis of 4-(Carbonyloxyphenyl)-1,4-dihydropyridines as potential antihypertensive agents

Bansal, R., Narang, G., Calle, C., Carron, R., Pemberton, K. & Harvey, A. L., 1 Feb 2013, In : Drug Development Research. 74, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J., Rathnam, R. P., Harvey, A. L., Clements, C. J., Clark, R. L., Barrett, M. P., Wong, P. E., Male, L., Coles, S. J. & Mackay, S. P., 1 Mar 2011, In : Bioorganic and Medicinal Chemistry . 19, 5, p. 1802-1815 14 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
Open Access
File
44 Downloads (Pure)

Snake toxins from mamba venoms: unique tools for the physiologist

Rowan, E. G. & Harvey, A. L., 2011, In : Acta Chimica Slovenica. 58, 4, p. 689-692 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Snake peptides

Harvey, A. L., 1 Jan 2013, Handbook of Biologically Active Peptides. Kastin, A. (ed.). p. 451-460 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Screening methods for drug discovery from plants

Harvey, A., 1 Jun 2012, Plant Bioactives and Drug Discovery: Principles, Practice and Perspectives. Cechinel-Filho, V. (ed.). p. 489-498 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Wallace Hayes, A., Gooderham, N., Harvey, A. & Barile, F. A., 15 Dec 2013, In : Toxicon. 76, p. A1-A2 2 p.

Research output: Contribution to journalEditorial

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N. & Harvey, A., 1 Sep 2013, In : Toxicology Research. 2, 5, p. 297-298 2 p.

Research output: Contribution to journalEditorial

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N., Harvey, A. & Barile, F. A., 15 Dec 2013, In : Toxicon. 76, p. A1-A2 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Batta Gori, G., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Wallace Hayes, A., Gooderham, N. & Harvey, A., 2013, In : ALTEX : Alternatives to Animal Experimentation . 30, 3, p. 381-382 2 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O. P., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N. & Harvey, A., Oct 2013, In : Toxicology in Vitro. 27, 7, p. 2110-2114 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., Aulock, S. V., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O., Lang, F., Barile, F. A., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N. & Harvey, A., 5 Sep 2013, In : Chemico-Biological Interactions. 205, 1, p. A1-A5 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Kehrer, J., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N. & Harvey, A., Dec 2013, In : Food and Chemical Toxicology. 62, p. A1-A4 4 p.

Research output: Contribution to journalArticle

Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids

Harvey, A. L., Young, L. C., Viljoen, A. M. & Gericke, N. P., 11 Oct 2011, In : Journal of Ethnopharmacology. 137, 3, p. 1124–1129 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Open letter to the European Commission: scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles

Dietrich, D., von Aulock, S., Marquardt, H. W. J., Blaauboer, B. J., Dekant, W., Kehrer, J., Hengstler, J. G., Collier, A. C., Gori, G. B., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N. & Harvey, A., Sep 2013, In : Archives of Toxicology. 87, 9, p. 1739-1741 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Natural product-based libraries

Harvey, A., 1 Mar 2014, Plant Chemical Biology. Audenaert, D. & Overvoorde, P. (eds.). p. 64-72 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microgram-scale, in vivo natural product discovery using zebrafish bioassays, UHPLC-TOF-MS and microflow NMR: identification of anticonvulsants in the Philippine medicinal plant Solanum torvum

Crawford, A. D., Challal, S., Buenafe, O. E., Harvey, A. L., Esguerra, C. V., De Witte, P. A. & Wolfender, J., 2011, In : Planta Medica. 77, 12, p. 1348-1349 2 p., PG70.

Research output: Contribution to journalConference Contribution

Memory impairment in rats by hippocampal administration of the serine protease subtilisin

Kornisiuk, E., Snitcofsky, M., Blanco, C., Harvey, A. L., Stone, T. W. & Jerusalinsky, D., 16 May 2011, In : Behavioural Brain Research. 219, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers

Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R. & 4 others, Suckling, C. J., Sutcliffe, O. B., Young, L. C. & MacKay, S. P., 24 Jul 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
131 Downloads (Pure)

Individual variability of venom from the European adder (Vipera berus berus) from one locality in Eastern Hungary

Malina, T., Krecsák, L., Westerström, A., Szemán-Nagy, G., Gyémánt, G., M-Hamvas, M., Rowan, E. G., Harvey, A. L., Warrell, D. A., Pál, B., Rusznák, Z. & Vasas, G., 1 Sep 2017, In : Toxicon. 135, p. 59-70 12 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
36 Downloads (Pure)

Improved method for the isolation, characterization and examination of neuromuscular and toxic properties of selected polypeptide fractions from the crude venom of the Taiwan cobra Naja naja atra

Ständker, L., Forssmann, W. G., Béress, L., Harvey, A. L., Fürst, S., Mathes, I. & Escalona de Motta, G., 15 Sep 2012, In : Toxicon. 60, 4, p. 623-631 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

From venoms to drugs: introduction

Harvey, A. L. & Stöcklin, R., 15 Mar 2012, In : Toxicon. 59, 4, p. 433 1 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Friends or foes? Emerging impacts of biological toxins

Clark, G. C., Casewell, N. R., Elliott, C. T., Harvey, A. L., Jamieson, A. G., Strong, P. N. & Turner, A. D., 1 Apr 2019, In : Trends in Biochemical Sciences . 44, 4, p. 365-379 15 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
6 Downloads (Pure)

Efecto inhibitorio de un extracto acuoso de las hojas de Allophylus cominia (L.) Sw sobre las proteínas tirosina fosfatasa 1B y dipeptidil peptidasa IV

Translated title of the contribution: Inhibitory effect of Allophylus cominia (L.) Sw leaves aqueous extract on tyrosine phosphatase 1B and dipeptidyl peptidase IV proteinsSánchez Calero, J., Young, L. C., Marrero Faz, E. & L. Harvey, A., 30 Jun 2014, In : Revista Cubana de Farmacia. 48, 4, p. 672-683 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
25 Downloads (Pure)

Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2

Translated title of the contribution: Inhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetesMarrero-Faz, E., Sánchez-Calero, J., Young, L. & Harvey, A., 1 Jan 2014, In : Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas . 13, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
254 Downloads (Pure)

Editorial: Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Dietrich, D. R., von Aulock, S., Marquardt, H., Blaauboer, B., Dekant, W., Hengstler, J., Collier, A., Gori, G. B., Pelkonen, O., Lang, F., Nijkamp, F. P., Stemmer, K., Li, A., Savolainen, K., Hayes, A. W., Gooderham, N. & Harvey, A., Dec 2013, In : Regulatory Toxicology and Pharmacology. 67, 3, p. 317-320 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Design, synthesis and evaluation of novel 16-imidazolyl substituted steroidal derivatives possessing potent diversified pharmacological properties

Bansal, R., Guleria, S., Thota, S., Bodhankar, S. L., Patwardhan, M. R., Zimmer, C., Hartmann, R. W. & Harvey, A. L., May 2012, In : Steroids. 77, 6, p. 621-629 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling

Gebruers, E., Cordero-Maldonado, M. L., Gray, A. I., Clements, C., Harvey, A. L., Edrada-Ebel, R., de Witte, P. A. M., Crawford, A. D. & Esguerra, C. V., 2013, In : PLOS One. 8, 12, p. e83293

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
87 Downloads (Pure)

A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A(1) receptors and enhances consolidation of step-down avoidance

Harvey, A. L., Young, L. C., Kornisiuk, E., Snitcofsky, M., Colettis, N., Blanco, C., Jerusalinsky, D., Jamieson, A. G., Hartley, R. C. & Stone, T. W., 1 Oct 2012, In : Behavioural Brain Research. 234, 2, p. 184-191 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)