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  • Ruangelie Edrada-Ebel
2019

Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study

do Nascimento, T. G., dos Santos Arruda, R. E., da Cruz Almeida, E. T., dos Santos Oliveira, J. M., Basílio-Júnior, I. D., Celerino de Moraes Porto, I. C., Rodrigues Sabino, A., Tonholo, J., Gray, A., Edrada Ebel, R., Clements, C., Zhang, T. & Watson, D. G., 4 Dec 2019, In : Scientific Reports. 9, p. 1-16 16 p., 18293.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
4 Downloads (Pure)

Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis

Siheri, W., Ebiloma, G. U., Igoli, J. O., Gray, A. I., Biddau, M., Akrachalanont, P., Samya Sh M D Alenezi, S., Alwashih, M. A., Edrada Ebel, R., Müller, S., Lawrence, C. E., Fearnley, J., Watson, D. G. & De Koning, H. P., 15 Mar 2019, In : Molecules. 24, 6, 12 p., 1041.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
11 Downloads (Pure)

Identification of GSK-3 as a potential therapeutic entry point for epilepsy

Aourz, N., Serruys, A-S. K., Chabwine, J. N., Balegamire, P. B., Afrikanova, T., Edrada-Ebel, R., Grey, A. I., Kamuhabwa, A. R., Walrave, L., Esguerra, C. V., van Leuven, F., de Witte, P. A. M., Smolders, I. & Crawford, A. D., 17 Apr 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1992-2003 12 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
15 Downloads (Pure)
2020

Morphological, genotypic and metabolomic signatures confirm interfamilial hybridization between the ubiquitous kelps Macrocystis (Arthrothamnaceae) and Lessonia (Lessoniaceae)

Murúa, P., Edrada-Ebel, R. A., Muñoz, L., Soldatou, S., Legrave, N., Müller, D. G., Patiño, D. J., can West, P., Küpper, F. C., Westermeier, R., Ebel, R. & Peters, A. F., 19 May 2020, In : Scientific Reports. 10, 1, 15 p., 8279.

Research output: Contribution to journalArticle

Open Access
File
2016

In vivo investigation of female reproductive functions and parameters in nonpregnant mice models and mass spectrometric analysis of the methanol leaf extract of Emilia Coccinea (Sims) G Dons

Elvis-Offiah, U. B., Bafor, E. E., Eze, G. I., Igbinumwen, O., Viegelmann, C. & Edrada-Ebel, R., 16 Dec 2016, In : Physiological Reports. 4, 23, e13047.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
1184 Downloads (Pure)
2017

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
92 Downloads (Pure)
2016

Isolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity

Alshaibani, M. M., Jalil, J., Sidik, N. M., Edrada-Ebel, R. & Zin, N. M., 31 May 2016, In : Drug Design, Development and Therapy. 10, p. 1817-1827 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
80 Downloads (Pure)
2019

Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt

Sebak, M., Saafan, A. E., AbdelGhani, S., Bakeer, W., El-Gendy, A. O., Castaño Espriu, L., Duncan, K. & Edrada-Ebel, R., 30 Dec 2019, In : PLOS One. 14, 12, 29 p., e0226959.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)
2018
Open Access
File
2 Citations (Scopus)
11 Downloads (Pure)
2019
2017
Open Access
File
4 Citations (Scopus)
98 Downloads (Pure)
2019

Tocolytic activity assessment of the methanol leaf extract of Justicia flava Vahl (Acanthaceae) on mouse myometrial contractility and preliminary mass spectrometric determination of secondary metabolites

Bafor, E. E., Ukpebor, F., Omoruyi, O., Ochoyama, E., Omogiade, G., Ekufu, J. & Edrada-Ebel, R., 28 Oct 2019, In : Journal of Ethnopharmacology. 243, 12 p., 112087.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
Open Access
File
11 Citations (Scopus)
7 Downloads (Pure)
2016

Using molecular networking for microbial secondary metabolite bioprospecting

Purves, K., Macintyre, L., Brennan, D., Hreggviðsson, G. Ó., Kuttner, E., Ásgeirsdóttir, M. E., Young, L. C., Green, D. H., Edrada-Ebel, R. & Duncan, K., 8 Jan 2016, In : Metabolites. 6, 1, 18 p., 2.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
79 Downloads (Pure)

Metabolomics-guided isolation of anti-trypanosomal metabolites from the endophytic fungus Lasiodiplodia theobromae

Kamal, N., Viegelmann, C. V., Clements, C. J. & Edrada-Ebel, R., 19 Oct 2016, In : Planta Medica.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
46 Downloads (Pure)

Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants

Sampaio, B. L., Edrada-Ebel, R. & Da Costa, F. B., 7 Jul 2016, In : Scientific Reports. 6, 29265.

Research output: Contribution to journalArticle

Open Access
File
123 Citations (Scopus)
62 Downloads (Pure)
2019
2016
Open Access
File
5 Citations (Scopus)
23 Downloads (Pure)

Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345

Cheng, C., Othman, E. M., Fekete, A., Krischke, M., Stopper, H., Edrada-Ebel, R. A., Mueller, M. J., Hentschel, U. & Abdelmohsen, U. R., 14 Sep 2016, In : Tetrahedron Letters. 57, 37, p. 4196-4199 4 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
237 Downloads (Pure)
2017
Open Access
File
15 Downloads (Pure)
2016

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Omar, R. M. K., Igoli, J., Gray, A. I., Ebiloma, G. U., Clements, C., Fearnley, J., Edrada Ebel, R. A., Zhang, T., De Koning, H. P. & Watson, D. G., 31 Mar 2016, In : Phytochemical Analysis. 27, 2, p. 107–115 9 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
125 Downloads (Pure)

Anti-infective activities of secondary metabolites from Vitex pinnata

Kamal, N., Clements, C., Gray, A. I. & Edrada-Ebel, R., 26 Jan 2016, In : Journal of Applied Pharmaceutical Science. 6, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
142 Downloads (Pure)
2020

Metabolomics-guided isolation of anti-trypanosomal compounds from endophytic fungi of the mangrove plant Avicennia lanata

Mazlan, N. W., Tate, R., Yusoff, Y. M., Clements, C. & Edrada-Ebel, R., 1 Jan 2020, In : Current Medicinal Chemistry. 27, 11, p. 1815-1835 21 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
2018

Metabolomic-guided isolation of bioactive natural products from Curvularia sp., an endophytic fungus of Terminalia laxiflora

Tawfike, A. F., Abbott, G., Young, L. & Edrada-Ebel, R., 28 Feb 2018, In : Planta Medica. 84, 3, p. 182-190 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
14 Downloads (Pure)

Modulation of ex-vivo uterine contraction by the methanol leaf extract of Alchornea laxiflora Benth. (Euphorbiaceae) and preliminary spectrometric identification of associated secondary metabolites

Bafor, E. E., Nwogu, J. K., Elvis-Offiah, U. B., Amaechina, F., Ofeimun, J., Ayinde, B., Omoruyi, O., Viegelmann, C. & Edrada-Ebel, R., 6 Jun 2018, In : Journal of Medicinal Plants For Economic Development. 2, 1, 13 p., a33.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)
2017

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

Thomson, S., Rice, C. A., Zhang, T., Edrada-Ebel, R., Henriquez, F. L. & Roberts, C. W., 15 Aug 2017, In : Scientific Reports. 7, 1, 9 p., 8247.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
80 Downloads (Pure)
2018

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri

Hamed, A. N. E., Schmitz, R., Bergermann, A., Totzke, F., Kubbutat, M., Müller, W. E. G., Youssef, D. T. A., Bishr, M. M., Kamel, M. S., Edrada-Ebel, R., Wätjen, W. & Proksch, P., 25 Apr 2018, In : Zeitschrift fur Naturforschung C. 73, 5-6, p. 199-210 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
8 Downloads (Pure)
2017

Isolation of petrocidin A, a new cytotoxic cyclic dipeptide from the marine sponge-derived bacterium Streptomyces sp. SBT348

Cheng, C., Othman, E. M., Stopper, H., Edrada-Ebel, R., Hentschel, U. & Abdelmohsen, U. R., 6 Dec 2017, In : Marine Drugs. 15, 12, 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
19 Downloads (Pure)
2018

A metabolomics approach to optimization of bioactive peptide production in marine bacterial co-cultures

Michelin, B. & Edrada-Ebel, R., 14 Nov 2018.

Research output: Contribution to conferencePoster

2017

P43 The isolation and purification of bioactive metabolites from Ficus carica and their neuroprotective effects in Alzheimer's disease

Khojah, H. & Edrada-Ebel, R., 1 Sep 2017, In : Biochemical Pharmacology. 139, Supplement C, p. 140 1 p.

Research output: Contribution to journalMeeting abstract

2020

Metabolomic tools used in marine natural product drug discovery

Stuart, K. A., Welsh, K., Walker, M. C. & Edrada-Ebel, R., 2 Apr 2020, In : Expert Opinion on Drug Discovery. 15, 4, p. 499-522 24 p.

Research output: Contribution to journalReview article

2017

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin, N. M., Baba, M. S., Zainal-Abidin, A. H., Latip, J., Mazlan, N. W. & Edrada-Ebel, R., 8 Feb 2017, In : Drug Design, Development and Therapy. 11, p. 351-363 13 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
304 Downloads (Pure)

The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei

Omar, R., Igoli, J. O., Zhang, T., Gray, A. I., Ebiloma, G. U., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., de Koning, H. P. & Watson, D. G., 19 Apr 2017, In : Scientific Reports. 7, 1, 10 p., 01038.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
45 Downloads (Pure)
2019

Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta)

Raheem, D. J., Tawfike, A. F., Abdelmohsen, U. R., Edrada-Ebel, R. & Fitzsimmons-Thoss, V., 22 Feb 2019, In : Scientific Reports. 9, 13 p., 2547 .

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
12 Downloads (Pure)
2018

SeaBioTech: from seabed to test-bed: harvesting the potential of marine biodiversity for industrial biotechnology

Edrada-Ebel, R., Ævarsson, A., Polymenakou, P., Hentschel, U., Carettoni, D., Day, J., Green, D., Hreggviðsson, G. Ó., Harvey, L. & McNeil, B., 28 May 2018, Grand Challenges in Marine Biotechnology. Rampelotto, P. H. & Trincone, A. (eds.). Cham: Springer, p. 451-504 54 p. (Grand Challenges in Biology and Biotechnology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
1 Downloads (Pure)
2020

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

Hulme, H., Meikle, L. M., Strittmatter, N., van der Hooft, J. J. J., Swales, J., Bragg, R. A., Villar, V. H., Ormsby, M. J., Barnes, S., Brown, S. L., Dexter, A., Kamat, M. T., Komen, J. C., Walker, D., Milling, S., Osterweil, E. K., MacDonald, A. S., Schofield, C. J., Tardito, S., Bunch, J. & 6 others, Douce, G., Edgar, J. M., Edrada-Ebel, R., Goodwin, R. J. A., Burchmore, R. & Wall, D. M., 11 Mar 2020, In : Science Advances. 6, 11, 11 p., eaax6328.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
2 Downloads (Pure)
2018

Green tea inhibits uterine contractility in ex vivo (non-pregnant) mice models

Bafor, E. E., Eze, C., Omoruyi, O., Elvis-Offiah, B. U., Viegelmann, C. & Edrada-Ebel, R., 7 Jun 2018, In : Tropical Journal of Natural Product Research. 2, 6, p. 254-261 8 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)
2017

Dryopteris filix-mas (Dryopteridaceae) leaves inhibit mouse uterine activity

Bafor, E. E., Omokaro, W. O., Uwumarongie, O. H., Elvis-Offiah, U. B., Omoruyi, O., Edrada-Ebel, R. & Viegelmann, C. V., 25 Oct 2017, In : Journal of Medicinal Plants For Economic Development. 1, 1, 12 p., a25.

Research output: Contribution to journalArticle

Open Access
File
14 Downloads (Pure)
2016

Chemical and antimicrobial profiling of propolis from different regions within Libya

Siheri, W., Zhang, T., Ebiloma, G. U., Biddau, M., Woods, N., Hussain, M. Y., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., Müller, S., Carter, K. C., Ferro, V. A., De Koning, H. P. & Watson, D. G., 19 May 2016, In : PLOS One. 11, 5, 16 p., e0155355.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
86 Downloads (Pure)
2017

Isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces SUK 25 with antimicrobial and cytotoxic activities

Alshaibani, M. M., Zin, N., Jalil, J., Sidik, N. M., Ahmad, S. J., Kamal, N. & Edrada-Ebel, R., 28 Jul 2017, In : Journal of Microbiology and Biotechnology. 27, 7, p. 1249-1256 8 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
294 Downloads (Pure)
2019

New bioactive metabolites from the elicited marine sponge-derived bacterium Actinokineospora spheciospongiae sp. nov.

Tawfike, A., Attia, E. Z., Desoukey, S. Y., Hajjar, D., Makki, A. A., Schupp, P. J., Edrada-Ebel, R. & Abdelmohsen, U. R., 24 Jan 2019, In : AMB Express. 9, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
15 Downloads (Pure)