TY - JOUR
T1 - 7-12 Hz cortical oscillations
T2 - behavioral context and dynamics of prefrontal neuronal ensembles
AU - Sakata, S.
AU - Yamamori, T.
AU - Sakurai, Y.
PY - 2005/7/12
Y1 - 2005/7/12
N2 - 7-12Hz Oscillations, characterized by spindle-like high-voltage rhythmic spike components, appear in quiet immobile states of rats. However, it remains unclear what their relationships with preceding behavioral activities are and how prefrontal neuronal dynamics during these oscillations is. In the present study, we first determined the relationship of 7-12Hz oscillations with the wake-sleep cycle and preceding behavioral activities in several normal rat strains by recording electroencephalograms from the multiple cortical regions. Prolonged awake period transiently enhanced the following appearance of 7-12Hz oscillations, which were frequently followed by slow-wave sleep. The degree of transient enhancement under the task condition was similar to that by prolonged wakefulness under the no-task condition. In addition, by recording local-field potential and multi-unit activities in the medial prefrontal cortex, we determined the temporal dynamics of prefrontal neuronal activities in relation to 7-12Hz oscillations. Collective neuronal activities in medial prefrontal cortex were gradually organized into phase-locked patterns and showed highly synchronization during these oscillations. These dynamics were in temporal proximity to those of slow-wave activities (<4Hz). Since slow-wave activities are thought to synchronize large spatial domains, these results suggest that 7-12Hz oscillations are involved in the transition from the awake to sleep states by oscillatory entrainment of global cortical networks including the prefrontal neurons.
AB - 7-12Hz Oscillations, characterized by spindle-like high-voltage rhythmic spike components, appear in quiet immobile states of rats. However, it remains unclear what their relationships with preceding behavioral activities are and how prefrontal neuronal dynamics during these oscillations is. In the present study, we first determined the relationship of 7-12Hz oscillations with the wake-sleep cycle and preceding behavioral activities in several normal rat strains by recording electroencephalograms from the multiple cortical regions. Prolonged awake period transiently enhanced the following appearance of 7-12Hz oscillations, which were frequently followed by slow-wave sleep. The degree of transient enhancement under the task condition was similar to that by prolonged wakefulness under the no-task condition. In addition, by recording local-field potential and multi-unit activities in the medial prefrontal cortex, we determined the temporal dynamics of prefrontal neuronal activities in relation to 7-12Hz oscillations. Collective neuronal activities in medial prefrontal cortex were gradually organized into phase-locked patterns and showed highly synchronization during these oscillations. These dynamics were in temporal proximity to those of slow-wave activities (<4Hz). Since slow-wave activities are thought to synchronize large spatial domains, these results suggest that 7-12Hz oscillations are involved in the transition from the awake to sleep states by oscillatory entrainment of global cortical networks including the prefrontal neurons.
KW - high-voltage spindles
KW - mu rhythm
KW - sleep pressure
KW - spike-and-wave discharge
KW - synchronized oscillation
UR - http://www.scopus.com/inward/record.url?scp=23944507488&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2005.05.018
DO - 10.1016/j.neuroscience.2005.05.018
M3 - Article
C2 - 16019153
AN - SCOPUS:23944507488
SN - 0306-4522
VL - 134
SP - 1099
EP - 1111
JO - Neuroscience
JF - Neuroscience
IS - 4
ER -