7-12 Hz cortical oscillations: behavioral context and dynamics of prefrontal neuronal ensembles

S. Sakata, T. Yamamori, Y. Sakurai

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

7-12Hz Oscillations, characterized by spindle-like high-voltage rhythmic spike components, appear in quiet immobile states of rats. However, it remains unclear what their relationships with preceding behavioral activities are and how prefrontal neuronal dynamics during these oscillations is. In the present study, we first determined the relationship of 7-12Hz oscillations with the wake-sleep cycle and preceding behavioral activities in several normal rat strains by recording electroencephalograms from the multiple cortical regions. Prolonged awake period transiently enhanced the following appearance of 7-12Hz oscillations, which were frequently followed by slow-wave sleep. The degree of transient enhancement under the task condition was similar to that by prolonged wakefulness under the no-task condition. In addition, by recording local-field potential and multi-unit activities in the medial prefrontal cortex, we determined the temporal dynamics of prefrontal neuronal activities in relation to 7-12Hz oscillations. Collective neuronal activities in medial prefrontal cortex were gradually organized into phase-locked patterns and showed highly synchronization during these oscillations. These dynamics were in temporal proximity to those of slow-wave activities (<4Hz). Since slow-wave activities are thought to synchronize large spatial domains, these results suggest that 7-12Hz oscillations are involved in the transition from the awake to sleep states by oscillatory entrainment of global cortical networks including the prefrontal neurons.

Original languageEnglish
Pages (from-to)1099-1111
Number of pages13
JournalNeuroscience
Volume134
Issue number4
DOIs
Publication statusPublished - 12 Jul 2005

Keywords

  • high-voltage spindles
  • mu rhythm
  • sleep pressure
  • spike-and-wave discharge
  • synchronized oscillation

Fingerprint

Dive into the research topics of '7-12 Hz cortical oscillations: behavioral context and dynamics of prefrontal neuronal ensembles'. Together they form a unique fingerprint.

Cite this