TY - JOUR
T1 - 5-HT1A receptor activation potentiates the spinal motor behaviour produced by intrathecal injection of a 5-HT2 agonist in rats
AU - Dixon, D.M.
AU - Robinson, A.J.
AU - Fone, K.C.F.
PY - 1990/7/5
Y1 - 1990/7/5
N2 - Intrathecal administration of 5-hydroxytryptamine (5-HT) agonists produces a behavioural syndrome which includes lateral head weaving, reciprocal forepaw treading, wet-dog shakes (WDS) and back muscle contractions (BMC). While 5-HT 2 receptor activation evokes WDS and BMC (Fone et al., 1989), 5-HT1A receptors appear to be involved in reciprocal forepaw treadipg and lateral head weaving (Tricklebank et al., 1985). Recent evidence indicates that the behaviours evoked by systemic administration of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OHDPAT) are facilitated by co-administration of the selective 5-HT2 receptor agonist l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) (Arnt and Hyttel 1989). In the present study we determined whether behavioural interaction between these two 5-HT receptor subtypes occurs within the spinal cord.
AB - Intrathecal administration of 5-hydroxytryptamine (5-HT) agonists produces a behavioural syndrome which includes lateral head weaving, reciprocal forepaw treading, wet-dog shakes (WDS) and back muscle contractions (BMC). While 5-HT 2 receptor activation evokes WDS and BMC (Fone et al., 1989), 5-HT1A receptors appear to be involved in reciprocal forepaw treadipg and lateral head weaving (Tricklebank et al., 1985). Recent evidence indicates that the behaviours evoked by systemic administration of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OHDPAT) are facilitated by co-administration of the selective 5-HT2 receptor agonist l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) (Arnt and Hyttel 1989). In the present study we determined whether behavioural interaction between these two 5-HT receptor subtypes occurs within the spinal cord.
KW - spinal motor behaviour
KW - 5HT receptor subtypes
KW - wet-dog shakes (WDS)
KW - back muscle contractions (BMC)
UR - http://www.scopus.com/inward/record.url?scp=0025107999&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/journal/european-journal-of-pharmacology
U2 - 10.1016/0014-2999(90)92301-X
DO - 10.1016/0014-2999(90)92301-X
M3 - Article
AN - SCOPUS:0025107999
SN - 0014-2999
VL - 183
SP - 1952
EP - 1953
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 5
ER -