3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery

Sophia N. Economidou, Cristiane Patricia Pissinato Pere, Andrew Reid, Md. Jasim Uddin, James F.C. Windmill, Dimitrios A. Lamprou, Dennis Douroumis

Research output: Contribution to journalArticle

Abstract

3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA)for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymeric resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were formed on the needle surface by inkjet printing. The optimization of the printing process resulted in superior skin penetration capacity of the 3D printed microneedles compared to metal arrays with minimum applied forces varying within the range of 2 to 5 N. Micro-CT analysis showed strong adhesion of the coated films on the microneedle surface even after penetration to the skin. In vivo animal trials revealed fast insulin action with excellent hypoglycaemia control and lower glucose levels achieved within 60 min, combined with steady state plasma glucose over 4 h compared to subcutaneous injections.

LanguageEnglish
Pages743-755
Number of pages13
JournalMaterials Science and Engineering: C
Volume102
Early online date22 Apr 2019
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

Stereolithography
insulin
Insulin
delivery
Printing
lithography
glucose
printing
resins
Glucose
hypoglycemia
Skin
penetration
Resins
Sugar Alcohols
Disaccharides
Subcutaneous Injections
sugars
Hypoglycemia
needles

Keywords

  • 3D printing
  • microneedles
  • microcomputer tomography
  • inkjet coating
  • insulin

Cite this

Economidou, Sophia N. ; Pere, Cristiane Patricia Pissinato ; Reid, Andrew ; Uddin, Md. Jasim ; Windmill, James F.C. ; Lamprou, Dimitrios A. ; Douroumis, Dennis. / 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. In: Materials Science and Engineering: C . 2019 ; Vol. 102. pp. 743-755.
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3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. / Economidou, Sophia N.; Pere, Cristiane Patricia Pissinato; Reid, Andrew; Uddin, Md. Jasim; Windmill, James F.C.; Lamprou, Dimitrios A.; Douroumis, Dennis.

In: Materials Science and Engineering: C , Vol. 102, 01.09.2019, p. 743-755.

Research output: Contribution to journalArticle

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