@inproceedings{260b0542d2414ec693ec29ad6acd73aa,
title = "3D-printed high-resolution microchannels for contrast enhanced ultrasound research",
abstract = "Systemically circulating microbubbles are used as contrast agents to aid both drug targeting and delivery using ultrasound. Exploiting their acoustic behaviour in small diameter vessels is critical for both applications, but the highly controlled experiments required to support this are not possible in vivo and challenging in vitro. Experimental platforms with small diameter channels (below 200 microns) are not readily available nor able to represent vascular geometries, leaving the existence and extent of microbubble-microvessel interactions incompletely defined. In this work we present a 3D-printed microchannel platform using tissue-mimicking hydrogels featuring radii down to 75 microns. We demonstrate application to study microbubble behaviour via acoustic backscatter under controlled environments in physiologically-relevant conditions.",
keywords = "micrometers, in vivo, ultrasonic imaging, process control, morphology, acoustics, physiology, microbubbles, ultrasound contrast agents, backscatter, microvessels, 3D-printing",
author = "Roger Domingo-Roca and Lauren Gilmour and Lisa Asciak and Stylianos Sarrigiannidis and Oana Dobre and Manuel Salmeron-Sanchez and Mairi Sandison and Richard O'Leary and Joseph Jackson-Camargo and Helen Mulvana",
note = "This article was mistakenly omitted from the original submission to IEEE Xplore. It is now included as part of the conference record. {\textcopyright} 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works; 2021 IEEE International Ultrasonics Symposium, IUS 2021 ; Conference date: 11-09-2011 Through 16-09-2011",
year = "2022",
month = apr,
day = "27",
doi = "10.1109/ius52206.2021.9763442",
language = "English",
isbn = "9781665447775",
volume = "2021-January",
series = "2021 IEEE Ultrasonics Symposium (IUS)",
publisher = "IEEE",
pages = "1--4",
booktitle = "2021 IEEE International Ultrasonics Symposium (IUS)",
}