3D-printed high-resolution microchannels for contrast enhanced ultrasound research

Roger Domingo-Roca, Lauren Gilmour, Lisa Asciak, Stylianos Sarrigiannidis, Oana Dobre, Manuel Salmeron-Sanchez, Mairi Sandison, Richard O'Leary, Joseph Jackson-Camargo, Helen Mulvana

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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Abstract

Systemically circulating microbubbles are used as contrast agents to aid both drug targeting and delivery using ultrasound. Exploiting their acoustic behaviour in small diameter vessels is critical for both applications, but the highly controlled experiments required to support this are not possible in vivo and challenging in vitro. Experimental platforms with small diameter channels (below 200 microns) are not readily available nor able to represent vascular geometries, leaving the existence and extent of microbubble-microvessel interactions incompletely defined. In this work we present a 3D-printed microchannel platform using tissue-mimicking hydrogels featuring radii down to 75 microns. We demonstrate application to study microbubble behaviour via acoustic backscatter under controlled environments in physiologically-relevant conditions.
Original languageEnglish
Title of host publication2021 IEEE International Ultrasonics Symposium (IUS)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages1-4
Number of pages4
Volume2021-January
ISBN (Electronic)9781665403559
ISBN (Print)9781665447775
DOIs
Publication statusPublished - 27 Apr 2022
Event2021 IEEE International Ultrasonics Symposium, IUS 2021 - Virtual, Online, China
Duration: 11 Sept 201116 Sept 2011

Publication series

Name2021 IEEE Ultrasonics Symposium (IUS)
PublisherIEEE
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2021 IEEE International Ultrasonics Symposium, IUS 2021
Country/TerritoryChina
CityVirtual, Online
Period11/09/1116/09/11

Keywords

  • micrometers
  • in vivo
  • ultrasonic imaging
  • process control
  • morphology
  • acoustics
  • physiology
  • microbubbles
  • ultrasound contrast agents
  • backscatter
  • microvessels
  • 3D-printing

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