2-methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate

Rajni M. Bhardwaj, Alastair J. Florence*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In the title solvate, C17H20N4S· 2C3H8O, pairs of olanzapine molecules related by a centre of inversion stack along the a axis, forming columns, which are packed parallel to each other along the b axis, forming a sheet arrangement. The columns within these sheets are hydrogen bonded to each other through the propan-2-ol solvent molecules. The diazepine ring of the olanzapine exists in a puckered conformation with the thiophene and phenyl rings making a dihedral angle of 57.66 (7)° and the piperazine ring adopts a chair conformation with the methyl group in an equatorial position.

Original languageEnglish
Pages (from-to)o752-o753
Number of pages10
JournalActa Crystallographica Section E: Crystallographic Communications
Volume69
Issue number5
Early online date20 Apr 2013
DOIs
Publication statusPublished - 31 May 2013

Funding

RM thanks the Commonwealth Scholarship Commission for providing a scholarship.

Keywords

  • crystallography
  • olanzapine mol­ecules
  • propan-2-ol solvent mol­ecules

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