1,4-Pentadienyl-3-sulfonamides afford products including those resulting from disfavored 5-endo-trig reactions when subjected to radical cyclization conditions. Products resulting from pathways featuring 4-exo-trig cyclizations are also detected, even when the 4-exo-trig reaction leads to a highly strained bicyclo[3.2.0] ring system.
- 5-endo-trig reactions
- 4-exo-trig cyclizations
- ring system
Bommezijn, S., Martin, C. G., Kennedy, A. R., Lizos, D., & Murphy, J. A. (2001). 1,4-pentadienyl-3-sulfonamides: Frameworks for disfavored radical cascade cyclizations. Organic Letters, 3(21), 3405-3407. https://doi.org/10.1021/ol0166449