Abstract
Alternate Name: IPr.
Solubility: soluble in THF, hexane, toluene, ether, and most organic solvents.
Analysis of Reagent Purity: elemental microanalysis, NMR spectroscopy.
Preparative Methods: can be prepared under inert atmosphere3 utilizing dry, oxygen-free solvents.4 IPr·HCl2 and KOtBu were added to a NaH suspension in THF in the glove box (eq 1). The mixture was stirred for 1 h at room temperature, for 2 h at 60 °C, followed by overnight stirring at room temperature. THF was removed in vacuo, the product was extracted with hot hexanes, filtered through a pad of Celite, and the solvent removed in vacuo resulting in a white solid.2
Solubility: soluble in THF, hexane, toluene, ether, and most organic solvents.
Analysis of Reagent Purity: elemental microanalysis, NMR spectroscopy.
Preparative Methods: can be prepared under inert atmosphere3 utilizing dry, oxygen-free solvents.4 IPr·HCl2 and KOtBu were added to a NaH suspension in THF in the glove box (eq 1). The mixture was stirred for 1 h at room temperature, for 2 h at 60 °C, followed by overnight stirring at room temperature. THF was removed in vacuo, the product was extracted with hot hexanes, filtered through a pad of Celite, and the solvent removed in vacuo resulting in a white solid.2
| Original language | English |
|---|---|
| Specialist publication | e-EROS Encyclopaedia of Reagents for Organic Synthesis |
| Publisher | John Wiley & Sons Inc. |
| DOIs | |
| Publication status | Published - 31 Mar 2016 |
Keywords
- reagents
- organic synthesis