α-Cyclodextrin/aminobenzoic acid binding in salt solutions at different pH: dependence on guest structure

Anastasia O. Romanova, Ekaterina Chibunova, Roman S. Kumeev, Maxim V. Fedorov, Irina V. Terekhova

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Influence of Na+ and K+ cations on α-cyclodextrin guest-host complex formation with isomeric aminobenzoic acids was examined at different pH and temperature of 298.15K by 1H NMR and calorimetry methods. More pronounced influence of Na+ on inclusion complex formation of α-CD with aminobenzoic acid anions compare to the effects of Na+ on α-CD complex formation with zwitterionic aminobenzoic acid molecules was revealed. For the first time, the dependence of salt effects on the structure, ionization and the hydration state of the guest molecule was demonstrated and analysed on the basis of the obtained thermodynamic parameters of complex formation and calculated free energy of hydration of different ionized forms of aminobenzoic acids.
Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalInternational Journal of Biological Macromolecules
Volume57
DOIs
Publication statusPublished - 1 Jun 2013

Keywords

  • cyclodextrin aminobenzoic acids
  • guest-host binding
  • hydration
  • inclusion complex formation
  • salt effect

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