Isolating active pharmaceutical ingredients (APIs) of specified purity and particle size distribution is an economically important industrial process. Problems with product composition and performance can arise from uncontrolled processes that occur during filtration, washing and drying. Physical transformations during these stages are very poorly understood. We will use both in situ 2D imaging and ex situ 3D tomography to elucidate the effects of API morphology, particle size/distribution, and wash solvent miscibility and concentration. The results will inform best practice in process design and operation to minimise out of specification product via mechanistic understanding of the dissolution/precipitation/redistribution of impurities and agglomeration. We hope to pinpoint microstructural variations in the porous bed and the location of impurities and residual mother liquor inclusions.
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.