Understanding the relationship between target affinities of bi-specific antibodies to dual cell-membrane targets and their impact on cell binding and selectivity to improve the accuracy and value of in silico modelling for prediction of the optimal target affinities for effective clinical outcomes

Rattray, Zahra (Principal Investigator)
Beveridge, Rebecca (Principal Investigator)
Duxbury, Rachel (Post Grad Student)

Project: Research - Studentship

Status	Active
Effective start/end date	1/10/22 → 31/03/26

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

3 Poster

Exploiting bi-specific engagement: assessing monovalent vs bivalent binding
Duxbury, R., Beveridge, R., Jamieson, C., Jones, D., Jones, G. & Rattray, Z., 23 Apr 2024.
Research output: Contribution to conference › Poster
Improving bi-specific engagement: assessing monovalent vs bivalent binding
Duxbury, R., Beveridge, R., Jamieson, C., Jones, D., Jones, G. & Rattray, Z., 13 Mar 2024.
Research output: Contribution to conference › Poster
Selective bi-specific engagement: assessing monovalent vs bivalent binding
Duxbury, R., Beveridge, R., Jamieson, C. (ed.), Jones, D., Jones, G. & Rattray, Z., 21 Nov 2023.
Research output: Contribution to conference › Poster

Understanding the relationship between target affinities of bi-specific antibodies to dual cell-membrane targets and their impact on cell binding and selectivity to improve the accuracy and value of in silico modelling for prediction of the optimal target affinities for effective clinical outcomes

Project Details

UN Sustainable Development Goals

Research output

Exploiting bi-specific engagement: assessing monovalent vs bivalent binding

Improving bi-specific engagement: assessing monovalent vs bivalent binding

Selective bi-specific engagement: assessing monovalent vs bivalent binding