SMALL MOLECULE ANALOGUES (SMA'S) OF AN IMMUNOMDULATORY HELMINTH PRODUCT PROVIDE A NOVEL APPROACH TO DISSECTING MACROPHAGE SIGNAL TRANDUCTION PATHWAYS

Project: Research

Research Output

2018

Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease

Doonan, J., Thomas, D., Wong, M. H., Ramage, H. J., Al-Riyami, L., Lumb, F. E., Bell, K. S., Fairlie-Clarke, K. J., Suckling, C. J., Michelsen, K. S., Jiang, H-R., Cooke, A., Harnett, M. M. & Harnett, W., 17 Oct 2018, In : Molecules. 23, 10, 14 p., 2669.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
9 Downloads (Pure)

Small molecule analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Suckling, C. J., Alam, S., Olson, M. A., Saikh, K. U., Harnett, M. M. & Harnett, W., 1 Feb 2018, In : Scientific Reports. 8, 11 p., 2123.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
19 Downloads (Pure)
2016

Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens

Janicova, L., Rzepecka, J., Rodgers, D. T., Doonan, J., Bell, K., Lumb, F. E., Suckling, C. J., Harnett, M. M. & Harnett, W., 30 Jun 2016, In : Parasite Immunology. 38, 6, p. 340-351 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
42 Downloads (Pure)
2015

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Rzepecka, J., Pineda, M. A., Al-Riyami, L., Rodgers, D. T., Huggan, J. K., Lumb, F. E., Khalaf, A. I., Meakin, P. J., Corbet, M., Ashford, M. L., Suckling, C. J., Harnett, M. M. & Harnett, W., Jun 2015, In : Journal of Autoimmunity. 60, p. 59-73 15 p.

Research output: Contribution to journalArticle

Open Access
File
46 Citations (Scopus)
2266 Downloads (Pure)
2014

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, J., Coates, M., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J., Janicova, L., Khalaf, A., Siebeke, I., Suckling, C., Harnett, M. & Harnett, W., Aug 2014, In : International Journal for Parasitology. 44, 9, p. 669-674 6 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
84 Downloads (Pure)
2013
56 Citations (Scopus)
2010

Small molecule analogues of an immunomodulatory helminth product provide a novel approach to dissecting macrophage signal transduction pathways: Poster abstract

Al-Riyami, L., Rzepecka, J., Khalaf, A., Suckling, C., Harnett, M. & Harnett, W., Dec 2010, In : Immunology. 131, Supplement 1, p. 164-164 1 p.

Research output: Contribution to journalArticle

2008

The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis

Harnett, M. M., Kean, D. E., Boitelle, A., McGuiness, S., Thalhamer, T., Steiger, C. N., Egan, C., Al-Riyami, L., Alcocer, M. J. C., Houston, K. M., Gracie, J. A., McInnes, I. B. & Harnett, W., 2008, In : Annals of the Rheumatic Diseases. 67, 4, p. 518-523 6 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Therapeutic immunomodulaors from nematode parasites

Harnett, W. & Harnett, M. M., Jun 2008, In : Expert Reviews in Molecular Medicine. 10, e18

Research output: Contribution to journalArticle

31 Citations (Scopus)