Self organisation in the immune system

  • Grimble, Michael (Principal Investigator)
  • Brewer, James, (Co-investigator)
  • Garside, Paul, (Co-investigator)
  • Giovanini, Leonardo, (Co-investigator)
  • Oppo, Gian-Luca (Co-investigator)

Project: Research

Description

The in vivo visualization of dynamic processes in lymphoid tissues by two-photon microscopy opens up possibilities for a combination of modelling, testing and experimental approaches to understand the behaviour of the immune system. A key element to develop larger models of immune response is the understanding of the cell activation, proliferation and interaction mechanisms. The aim of the project is to develop a theoretical and algorithmic framework to model and simulate the behaviour of T-cells in different environments and conditions using multi/agent dynamic systems and self-organizing systems. The proposed framework will reduce the burden on the modeling and simulation of immune system. A major step forward will be achieved by drawing inspiration from behavioural science, control engineering, physical and mathematical modelling. The final multi-agent model represents a multi-discipline integration of research concepts and simultaneously a substantial improvement of the present state of the art that fails to identify the mechanisms responsible for T-cell activation and proliferation. The integration of the activities in three research units at Strathclyde guarantees the accuracy of the final model that will be tested against a variety of experimental data and put the applicants in a unique position for the achievement of the objectives not just in the UK but also at an international level.
StatusFinished
Effective start/end date1/08/0731/10/08

Funding

  • EPSRC (Engineering and Physical Sciences Research Council): £106,290.00

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Immune system
T-cells
Drawing (graphics)
Chemical activation
Microscopic examination
Dynamical systems
Visualization
Photons
Tissue
Testing