Peptoid Biomaterials

Poly(N-substituted glycine) “peptoids” are a novel class of synthetic sequence-controlled, peptidomimetic polymers that are structural isomers of peptides with sidechains connected to the amide nitrogens. They were originally developed as a synthetically convenient combinatorial drug discovery platform, and many bioactive sequences have been discovered. This research will develop peptoids as functional biomaterials with properties that can be conveniently tuned by the peptoid residue sequence and that can direct the behaviour of cells cultured on them.