Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis

Project: Research Fellowship

Description

This project seeks to investigate the role of proteinase-activated receptors (PARs) in HMGB1-mediated platelet activity in response to thrombin. This will be followed by the study of chemotherapeutic influence on thrombin-mediated platelet HMGB1 release and any associated impact upon oxidized HMGB1 levels and platelet and vascular cell function.
StatusActive
Effective start/end date1/09/1931/08/20

Keywords

  • HMGB1
  • Thrombin
  • Chemotherapy
  • Cardiovascular
  • Platelet
  • Neuropathy