Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis

Project: Research Fellowship

Project Details

Description

This project seeks to investigate the role of proteinase-activated receptors (PARs) in HMGB1-mediated platelet activity in response to thrombin. This will be followed by the study of chemotherapeutic influence on thrombin-mediated platelet HMGB1 release and any associated impact upon oxidized HMGB1 levels and platelet and vascular cell function.
StatusFinished
Effective start/end date1/09/1931/08/20

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education
  • SDG 10 - Reduced Inequalities

Keywords

  • HMGB1
  • Thrombin
  • Chemotherapy
  • Cardiovascular
  • Platelet
  • Neuropathy

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