Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis

Domoto, Risa (Principal Investigator)
Cunningham, Margaret Rose (Principal Investigator)
Kawabata, Atsufumi (Co-investigator)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Kindai University, Graduate School of Pharmacy, Japan

Project: Research Fellowship

Description

This project seeks to investigate the role of proteinase-activated receptors (PARs) in HMGB1-mediated platelet activity in response to thrombin. This will be followed by the study of chemotherapeutic influence on thrombin-mediated platelet HMGB1 release and any associated impact upon oxidized HMGB1 levels and platelet and vascular cell function.

Status	Finished
Effective start/end date	1/09/19 → 31/08/20

Keywords

HMGB1
Thrombin
Chemotherapy
Cardiovascular
Platelet
Neuropathy

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This work is funded by a Canon Foundation in Europe Fellowship

Regulation of High Mobility Group Box 1 (HMGB1) protein from human microglial cells in response to thrombin
Cunningham, M. R. & Butler, L.
1/10/18 → 31/08/19
Project: Research

Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis

Project Details

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Keywords

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Regulation of High Mobility Group Box 1 (HMGB1) protein from human microglial cells in response to thrombin

Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis

Project Details

Description

Keywords

Access Project

Fingerprint

Projects

Regulation of High Mobility Group Box 1 (HMGB1) protein from human microglial cells in response to thrombin