Macromolecular construction of DNA networks directed by the fluorous effect

Project: Research

Project Details


This project is focused on:
(i) Development of robust and orthogonal molecular recognition modalities at DNA nanostructure interfaces. Auxiliary molecular recognition modes which complement W-C base-pairing would be highly desirable as they could direct novel assembly processes not readily available using W-C base-pairing in isolation;
(ii) Systematic characterisation of the kinetics and thermodynamics of DNA nanostructure interfaces. A detailed understanding of the kinetic and thermodynamic parameters influencing hierarchical assembly will be essential to optimize desired assembly pathways whilst minimizing incorrectly formed complexes;
(iii) Development of methodology to integrate micron-scale, 3D DNA nanostructure networks in defined surface patterns

Layman's description

This work is focused on combining the fluorous effect with DNA origami to develop new ways of controlling DNA assembly.
Effective start/end date1/11/1831/10/21