Investigation of co-solvency and co-nonsolvency effects, based on the structure of water-alcohol mixture

  • Zhang, Zhenyu (Academic)
  • Geoghegan, Mark (Academic)
  • Bowron, Daniel (Academic)

Project: Research

Project Details


Co-solvency is a phenomenon where a small quantity of co-solvent is added to a bulk solvent to enhance the solubility of a desired solute in the mixture. Correspondingly, there is a second effect, co-nonsolvency, where a solute of interest, 2-(methacryloyloxy)ethylphosphorylcholine) (MPC) in this study, is soluble in either of the pure solvents used in a co-solvent mixture, but not in a mixture of specific compositional ratio. Despite much interest in these phenomena, there is currently little structural understanding of the in-solution molecular correlations that drives them. Here we propose to use H/D isotopic substitution neutron scattering methods to investigate the solution structure of ethanol-water-MPC at co-solvency/co-nonsolvency compositions to provide a baseline model of common media in which the effects take place.
Effective start/end date18/09/1323/09/13


  • Solid state physics. Nanoscience
  • neutron diffraction


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