Industrial Case Account 2012 | Malcolm, Andrew

Project: Research Studentship Case - Internally allocatedResearch Studentship CASE (Internally Allocated)

Key findings

Application of the Pauson-Khand cyclisation has been investigated in order to achieve rapid and efficient access to a number of sesquiterpene and sesquiterpeneoid natural products.

Throughout the period of research a number of Pauson-Khand cyclisation precursors have been synthesised and employed in an attempt to generate the carbon skeleton framework of a number of challenging tricyclic natural products. To date an efficient process has been found to construct an advanced intermediate towards the natural product sequithuriferone, which ultimately will allow access to several related natural products.
StatusFinished
Effective start/end date1/10/128/12/16

Funding

  • EPSRC (Engineering and Physical Sciences Research Council): £13,522.00

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skeleton
product
carbon