Project Details
Key findings
Application of the Pauson-Khand cyclisation has been investigated in order to achieve rapid and efficient access to a number of sesquiterpene and sesquiterpeneoid natural products.
Throughout the period of research a number of Pauson-Khand cyclisation precursors have been synthesised and employed in an attempt to generate the carbon skeleton framework of a number of challenging tricyclic natural products. To date an efficient process has been found to construct an advanced intermediate towards the natural product sequithuriferone, which ultimately will allow access to several related natural products.
Throughout the period of research a number of Pauson-Khand cyclisation precursors have been synthesised and employed in an attempt to generate the carbon skeleton framework of a number of challenging tricyclic natural products. To date an efficient process has been found to construct an advanced intermediate towards the natural product sequithuriferone, which ultimately will allow access to several related natural products.
| Status | Finished |
|---|---|
| Effective start/end date | 1/10/12 → 8/12/16 |
Funding
- EPSRC (Engineering and Physical Sciences Research Council): £6,022.00
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