EPSRC SEA - In-Vitro and In-Silico Tools for Drug Discovery and Development

80% of current marketed medication is in oral form however many newly identified medications fail to make it to the market due to low solubility and issues with movement of the drug through the intestinal tract and subsequent effects which is an inefficient use of time and resources. Our work is centred around understanding the relationship between the gut and the behaviour of the drug within the body. Previous research within our group has concentrated on developing a media that is representative of that of the gut and this study aims to expand this work by
understanding the media variability and its effect on the drug solubility. This data will be incorporated into a model that will predict the drug performance within the body and any challenges it may present at early drug development stages prior to market. Any challenges that are identified could be overcome through formulation adaptations.