EPSRC Pump Priming Project: A bi-wavelength nonlinear optical microscope for the assessment of cardiac fibrosis following hypertrophic remodelling using second harmonic generation

The aim of this project was to determine whether second harmonic generation (SHG) could be used as a more sensitive and less invasive technique for quantifying collagen deposition in the heart. Pilot experiments in this project assessed whether SHG could be used as a superior technology for accurate measurement of cardiac collagen deposition (fibrosis).