EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Russell, Ben Allan

  • Chen, Yu (Principal Investigator)
  • Mulheran, Paul (Co-investigator)
  • Russell, Ben Allan (Research Co-investigator)

Project: Research Studentship - Internally Allocated

Project Details

Key findings

From Fluorescence and computational studies of synthesised Human Serum Albumin Gold Nanoclusters the location of nanocluster nucleation and growth in the protein was found to be centred in the second domain, located near one of the major drug binding sites of the protein.

From hydrodynamic and adsorption technique studies it was found that both Lysozyme and Human Serum Albumin protein encapsulated Gold Nanoclusters form larger aggregates than the proteins natural form, as well as altering a number of important characteristics such as the isoelectric point and the viscosity.

From further fluorescence studies it was found that the gold nanocluster in Human Serum Albumin blocks the ability of the protein to bind to drug molecules at Sudlow site I of the protein. This was found during a series of experiments using the fluorescent drug Warfarin.
StatusFinished
Effective start/end date1/10/132/06/17

Funding

  • EPSRC (Engineering and Physical Sciences Research Council): £14,009.00

Research Output

Sudlow site II of human serum albumin remains functional after gold nanocluster encapsulation: a fluorescence-based drug binding study of L-Dopa

Russell, B. A., Garton, A., Alshammari, A. S., Birch, D. J. S. & Chen, Y., 2 Jul 2018, In : Methods and Applications in Fluorescence . 6, 3, 6 p., 035017.

Research output: Contribution to journalArticle

Open Access
File
  • 4 Citations (Scopus)
    3 Downloads (Pure)

    Locating the nucleation sites for protein encapsulated gold nanoclusters: a molecular dynamics and fluorescence study

    Russell, B. A., Kubiak-Ossowska, K., Mulheran, P. A., Birch, D. J. S. & Chen, Y., 22 Jul 2015, In : Physical Chemistry Chemical Physics. 17, 34, p. 21935-21941 7 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 28 Citations (Scopus)
    107 Downloads (Pure)

    Prizes

    Award for outstanding international students poster

    Ben Allan Russell (Recipient), 28 May 2015

    Prize: Prize (including medals and awards)

    Activities

    • 2 Participation in conference

    Horyzonty Nauki Forum Prac Dyplomowych 2015

    Ben Allan Russell (Participant)

    2015

    Activity: Participating in or organising an event typesParticipation in conference

    MAF14

    Ben Allan Russell (Participant)

    2015

    Activity: Participating in or organising an event typesParticipation in conference