Enzyme Responsive Materials For Biology And Medicine

Project: Research Fellowship

Description

This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.

Key findings

"- enzyme-responsive polymer hydrogels for controlled release of proteins. Developed methodology to match polymer functionality with protein payload. Developed two-photon microscopy to monitor controlled release.
- demonstrated ability to control and dire"
StatusFinished
Effective start/end date1/09/0831/07/11

Funding

  • EPSRC (Engineering and Physical Sciences Research Council): £366,972.00

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Medicine
Enzymes
Hydrogels
Polymers
Cell growth
Biocompatible Materials
Scaffolds (biology)
Drug delivery
Tissue engineering
Cell culture
Microscopic examination
Proteins
Photons
Gels
Pharmaceutical Preparations

Keywords

  • responsive materials
  • peptides
  • enzymes
  • controlled release
  • biocatalytic self-assembly
  • hydrogels