Endothelial acetylcholine release explains flow mediated dilation and is impaired in type 2 diabetes

McCarron, John (Principal Investigator)
Wilson, Calum (Co-investigator)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Project: Research

Description

Endothelial acetylcholine release accounts for flow-mediated dilation and is impaired in type 2 diabetes

Status	Finished
Effective start/end date	9/01/17 → 25/05/20

Funding

British Heart Foundation BHF: £204,947.00

7 Article

Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity
Wilson, C., Zhang, X., Lee, M. D., MacDonald, M., Heathcote, H. R., Alorfi, N. M. N., Buckley, C., Dolan, S. & McCarron, J. G., 1 Oct 2020, In: Metabolism. 111, 10 p., 154340.
Research output: Contribution to journal › Article › peer-review

Open Access
File
25 Citations (Scopus)

28 Downloads (Pure)
Hydrogen peroxide depolarizes mitochondria and inhibits IP₃-evoked Ca²⁺ release in the endothelium of intact arteries
Zhang, X., Lee, M. D., Wilson, C. & McCarron, J. G., 31 Dec 2019, In: Cell Calcium. 84, 12 p., 102108.
Research output: Contribution to journal › Article › peer-review

Open Access
File
22 Citations (Scopus)

33 Downloads (Pure)
Increased vascular contractility in hypertension results from impaired endothelial calcium signaling
Wilson, C., Zhang, X., Buckley, C., Heathcote, H. R., Lee, M. D. & McCarron, J. G., 1 Nov 2019, In: Hypertension. 74, 5, p. 1200-1214 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
55 Citations (Scopus)

51 Downloads (Pure)