The impurities in pharmaceuticals are unwanted chemicals that remain with the active pharmaceutical ingredients or develop during formulation or arise during aging of API and formulation. The presence of impurities in drugs may significantly change product quality and safety. Chromatography techniques are the most common techniques to monitor the drug substance and its impurities. In this PhD project the impurities present and their effects on the continuous crystallization environment will be studied. The research advances will be that by being able to quantify and understand the effects that certain impurity levels have on the crystallization, the chances of obtaining an ideal crystal product will be more likely. This in turn leads to a more effective overall process with greater efficiency.
|Effective start/end date||1/10/12 → 10/02/17|
- EPSRC (Engineering and Physical Sciences Research Council): £11,948.00
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