Research output per year
Research output per year
Project Details
Description
Based on the recently published PAR2 crystal structure, a novel series of PAR2 antagonists were developed - namely the AZ series. However these require further target validation and elucidation of there pharmacological properties, and from these novel derivatives will be developed.
Layman's description
Inhibiting the GPCR receptor PAR2 for the treatment of arthritis and inflammatory disease
Key findings
AZ-series appears to be a selective PAR2 antagonist, capable of inhibiting several downstream signalling pathways. Further work ex-vivo is on-going.
| Short title | PAR2 antagonists |
|---|---|
| Status | Active |
| Effective start/end date | 5/02/23 → 29/08/27 |
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Research output
- 1 Poster
-
Proteinase activated receptor 2: a novel therapeutic drug target
Lozon, Y., McIntosh, K. & Plevin, R., 8 Feb 2024.Research output: Contribution to conference › Poster
Projects
- 1 Active
-
Evaluation of protease activated receptor 2 (PAR2) as a novel therapeutic target for chronic obstructive pulmonary disease (COPD)
Crilly, A. (Principal Investigator) & McIntosh, K. (Academic)
17/10/22 → 31/10/25
Project: Research - Studentship