Developing novel inhibitors to prevent the induction of CXCL12 in breast cancer fibroblasts cells

Project: Internally funded project

Project Details


CXCL12 plays an important role in a number of diseases. In cancer it has a key role in sustaining the tumour microenvironment and is implicated in ovarian and breast cancers. One strategy is to develop new drugs that block the formation of CXCL12 prior to the activation of its receptor CXCR4. A screen conducted through SULSA-Biocity has lead to 50 propriety compounds to be taken forward for testing.

Layman's description

CXCL12 is a key inflammatory chemokine responsible for the metastasis of primary tumours to secondary sites. This study characterises novel CXCL12 inhibitors.


Joint 1st Supervisor of a PhD student - Mohammad Farhan, who is on a related/joined project.
Short titleTargerting CXCL12 in Breast cancer
Effective start/end date28/01/2329/01/28

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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